Chronic intestinal inflammation is associated with pathological angiogenesis that further amplifies the inflammatory response. Vascular endothelial growth factor (VEGF), is a major angiogenic cytokine that has been implicated in chronic colitis and …

Stiffness of large arteries has been long recognized as a significant determinant of pulse pres- sure. However, it is only in recent decades, with the accumulation of longitudinal data from large and varied epidemiological studies of morbidity and …

Orthotopic bladder cancer xenografts are essential for testing novel therapies and molecular manipulations of cell lines in vivo. Current xenografts rely on tumor cell inoculation by intravesical instillation or direct injection into the bladder wall. …

Spectral imaging is an advanced photo-acoustic (PA) mode that can discern optical absorption of contrast agent(s) in the tissue micro-environment. This advancement is made possible by precise control of optical wavelength using a tunable pulsed laser, …

Reporter genes are useful scientific tools for analyzing promoter activity, transfection efficiency, and cell migration. The current study has validated the use of tyrosinase (involved in melanin production) as a dual reporter gene for magnetic resonance …

Development of reporter genes for multimodality molecular imaging is highly important. In contrast to the conventional strategies which have focused on fusing several reporter genes together to serve as multimodal reporters, human tyrosinase (TYR)--the …

Angiostamp TM 800 is an organic near-infrared (NIR) fluorescent and photoacoustic imaging agent licensed by Optimal Grenoble, a small animal imaging team in France. It is a NIR imaging agent targeting the αvβ3 integrin. The αvβ3 integrin is overexpressed …

Stem Cell Tracking …

Inhibition or removal of excess reactive oxygen species can effectively protect cellular function or reduce cell death because oxidative stress is the main cause of cellular damage in many diseases. The flavonoid compound IcarisideII having a slight …

Current technology for penile hemodynamic evaluations in small animals is invasive and has limitations. We evaluated a novel laser speckle contrast imag- ing (LSCI) technique to determine age-related changes in penile microvascular perfusion (PMP) and …