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Effect of Shenmai injection on preventing the development of nitroglycerin-induced tolerance in rats
Long-term nitroglycerin (NTG) therapy causes tolerance to its effects attributing to increased oxidative stress and endothelial dysfunction. Shenmai injection (SMI), which is clinically used to treat cardiovascular diseases, consists of two herbal …
Publication
Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction
Background: Stem cell therapy has emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the poor viability of transplanted stem cells hampers their therapeutic efficacy. Hypoxic preconditioning (HPC) can effectively promote …
Publication
Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction
Background: Based on global gene expression profile, therapeutic effects ofQishenyiqi (QSYQ) on acute myocardial infarction (AMI) were investigated by integrated analysis at multiple levels including gene expression, pathways involved and functional …
Publication
Targeting chronic cardiac remodeling with cardiac progenitor cells in a murine model of ischemia/reperfusion injury
BACKGROUND Translational failure for cardiovascular disease is a substantial problem involving both high research costs and an ongoing lack of novel treatment modalities. Despite the progress already made, cell therapy for chronic heart failure in the …
Publication
Adenosine Formed by CD73 on T Cells Inhibits Cardiac Inflammation and Fibrosis and Preserves Contractile Function in Transverse Aortic Constriction–Induced Heart FailureCLINICAL PERSPECTIVE
Background—Structural damage during heart failure development leads to increased infiltration of leukocytes. Because purinergic signaling on immune cells may impact on the inflammatory response, we evaluated the role of ecto-5′- nucleotidase (CD73) on the …
Publication
Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction
Two distinct monocyte (Mo)/macrophage (Mp) subsets (Ly6Clow and Ly6Chigh) orchestrate cardiac recovery process following myocardial infarction (MI). Prostaglandin (PG) E2 is involved in the Mo/Mp-mediated inflammatory response, however, the role of its …
Publication
Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension
The typical cause of death in pulmonary hypertension (PH) is right ventricular (RV) failure, with females showing better survival rates than males. Recently, metabolic shift and mitochondrial dysfunction have been demonstrated in RV failure secondary to …
Publication
Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis
Recognition of cardiomyopathy in sepsis can be challenging due to the limitations of conventional measures such as ejection fraction (EF) and fractional shortening (FS) in the context of variable preload and afterload conditions. This study correlates …
Publication
Shenfuqiangxin Capsule inhibits apoptosis through mitogen-activated protein kinase signal pathway in rats with cardio-renal syndrome induced by infrarenal aortic-clamping
OBJECTIVE To investigate the effect of Shenfuqiangxin capsule and the underlying mechanism on cardio-renal syndrome (CRS) in rats induced by infrarenal aortic-clamping after renal ischaemia. METHODS Male Wistar rats underwent infrarenal aortic-clamping …
Publication
Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit
The Nkx2.5 gene encodes a transcription factor that plays a critical role in heart development. In humans, hetero- zygous mutations in NKX2.5 result in congenital heart defects (CHDs). However, the molecularmechanisms by which these mutations cause the …