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TRPC4α and TRPC4β Similarly Affect Neonatal Cardiomyocyte Survival during Chronic GPCR Stimulation
The Transient Receptor Potential Channel Subunit 4 (TRPC4) has been considered as a crucial Ca2+ component in cardiomyocytes promoting structural and functional remodeling in the course of pathological cardiac hypertrophy. TRPC4 assembles as homo or …
Publication
Activation of PPAR-α in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure
Failing heart loses its metabolic flexibility, relying increasingly on glucose as its preferential substrate and decreasing fatty acid oxidation (FAO). Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a key reg- ulator of this substrate …
Publication
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling
On pathological stress, Wnt signaling is reactivated and induces genes associated with cardiac remodeling and fibrosis. We have previously shown that a cell surface receptor Cdon (cell-adhesion associated, oncogene regulated) suppresses Wnt signaling to …
Publication
Cardiosphere-derived cells do not improve cardiac function in rats with cardiac failure
Background: Heart failure represents an important public health issue due to its high costs and growing incidence worldwide. Evidence showing the regenerative potential of postmitotic heart tissue has suggested the existence of endogenous cardiac stem …
Publication
Adeno-associated Virus Serotype 9 – Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts with Left Ventricular Dysfunction Secondary to a Myocardial Infarction
OBJECTIVES: The present study was undertaken to test the hypothesis that gene delivery of BCL2-Associated Athanogene 3 (BAG3) to the heart of mice with left ventricular dysfunction secondary to a myocardial infarction could enhance cardiac performance. …
Publication
ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance
Aims Obesity and type 2 diabetes (T2D) trigger a harmful stress-induced cardiac remodeling process known as cardiomyopathy. These diseases represent a serious and widespread health problem in the Western world; however, the underlying molecular basis is …
Publication
Genetic deletion of soluble epoxide hydrolase provides cardioprotective responses following myocardial infarction in aged mice
Background: Pathophysiological responses, including cardiovascular complications, often alter with age. Cardioprotective effects of epoxyeicosatrienoic acids (EETs) toward acute myocardial ischemia- reperfusion injury have been well documented. However, …
Publication
Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase
Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. OBJECTIVE Our goal was to investigate the mechanisms of endothelial Nox4 in regulating …
Publication
Development of an injectable pseudo-bone thermo-gel for application in small bone fractures
A pseudo-bone thermo-gel was synthesized and evaluated for its physicochemical, mechanical and rheological properties, with its application to treat small bone fractures. The pseudo-bone thermo-gel was proven to have thermo-responsive properties, behaving …
Publication
Effects of exercise training on brain-derived neurotrophic factor in skeletal muscle and heart of rats post myocardial infarction
Exercise training post myocardial infarction (MI) attenuates progressive left ventricle (LV) remodeling and dysfunction, but the peripheral stimuli induced by exercise which trigger these beneficial effects are still unclear. We investigated as possible …