Search
Publication
Anaesthetic-induced cardioprotection in an experimental model of the Takotsubo syndrome - isoflurane vs. propofol
Background: Takotsubo syndrome (TS) is an acute cardiac condi- tion with a substantial mortality for which no specific treatment is available. We have previously shown that isoflurane attenuates the development of left ventricular (LV) dysfunction in an …
Publication
Mechanisms of Chinese Medicine Xinmailong’s protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes
Patients with heart failure (HF) have high mortality and mobility. Xinmailong (XML) injection, a Chinese Medicine, is clinically effective in treating HF. However, the mechanism of XML’s effectiveness on HF was unclear, and thus, was the target of the …
Publication
Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice
Background-—Macrophages and Wnt proteins (Wnts) are independently involved in cardiac development, response to cardiac injury, and repair. However, the role of macrophage-derived Wnts in the healing and repair of myocardial infarction (MI) is unknown. We …
Publication
Antagonists of growth hormone-releasing hormone inhibit proliferation induced by inflammation in prostatic epithelial cells
The etiology of benign prostatic hyperplasia (BPH) is multifactorial, and chronic inflammation plays a pivotal role in its pathogenesis. Growth hormone-releasing hormone (GHRH) is a hypothalamic neuropeptide that has been shown to act as …
Publication
Reversal of maladaptive fibrosis and compromised ventricular function in the pressure overloaded heart by a caveolin-1 surrogate peptide
Chronic ventricular pressure overload (PO) results in congestive heart failure (CHF) in which myocardial fibrosis develops in concert with ventricular dysfunction. Caveolin-1 is important in fibrosis in various tissues due to its decreased expression in …
Publication
Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse
Ultrasonography is a powerful tool to non-invasively monitor in real time the development of the human fetus in utero. Although genetically engineered mice have served as valuable in vivo models to study both embryo implantation and pregnancy progression, …
Publication
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure
Background Although cardiac and splenic mononuclear phagocytes (MPs), i.e., monocytes, macro- phages and dendritic cells (DCs), are key contributors to cardiac remodeling after myo- cardial infarction, their role in pressure-overload remodeling is …
Publication
Complementary roles of gasotransmitters CO and H 2 S in sleep apnea
Sleep apnea, which is the periodic cessation of breathing during sleep, is a major health problem affecting over 10 million people in the United States and is associated with several sequelae, in- cluding hypertension and stroke. Clinical studies suggest …
Publication
Effect of chromatin structure on quantitative ultrasound parameters
High-frequency ultrasound (~20 MHz) techniques were investigated using in vitro and ex vivo models to determine whether alterations in chromatin structure are responsible for ultrasound backscatter changes in biological samples. Acute myeloid leukemia …
Publication
Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation
The present study focuses on the identification of the gene expression profile of neonatal rat cardiomyocytes (NRVCMs) after dynamic mechanical stretch through microarrays of RNA isolated fromcells stretched for 2, 6 or 24 h. In this analysis,myeloid …