Search
Publication
The Negative Chronotropic Effect in Rat Heart Stimulated by Ultrasonic Pulses: Role of Sex and Age
Objectives—The goal of this study is to investigate the role of sex and age of the negative chronotropic effect after exposure of 3.5-MHz pulsed ultrasound (US) to the rat heart. Methods—Forty F344 rats were exposed transthoracically to ultrasonic pulses …
Publication
Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress
Background-—Sex-related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure. However, whether similar …
Publication
Limiting the protein corona: A successful strategy for in vivo active targeting of anti-HER2 nanobody-functionalized nanostars
Gold nanoparticles hold great promise as anti-cancer theranostic agents against cancer by actively tar- geting the tumor cells. As this potential has been supported numerously during in vitro experiments; the effective application is hampered by our …
Publication
Transplantation of adipose-derived stem cells combined with neuregulin-microparticles promotes efficient cardiac repair in a rat myocardial infarction model
Tissue engineering is a promising strategy to promote heart regeneration after amyocardial infarction (MI). In this study, we investigated the reparative potential of a system that combines adipose-derived stem cells (ADSCs) withmicroparticles (MPs) …
Publication
Peptidomics Analysis of Transient Regeneration in the Neonatal Mouse Heart
Neonatal mouse hearts have completely regenerative capability after birth, but the ability to regenerate rapidly lost after 7 days, the mechanism has not been clarified. Previous studies have shown that mRNA profile of adult mouse changed greatly compared …
Publication
Inhibition of dynamin-related protein 1 protects against myocardial ischemia–reperfusion injury in diabetic mice
Background: Many cardioprotective pharmacological agents failed to exert their protective effects in diabetic hearts subjected to myocardial ischemia/reperfusion (MI/R). Identify the molecular basis linking diabetes with MI/R injury is scientifically …
Publication
Inhibition of dynamin-related protein 1 protects against myocardial ischemia–reperfusion injury in diabetic mice
Background: Many cardioprotective pharmacological agents failed to exert their protective effects in diabetic hearts subjected to myocardial ischemia/reperfusion (MI/R). Identify the molecular basis linking diabetes with MI/R injury is scientifically …
Publication
Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer
Background: Functionalized nanoparticles (NPs) are one promising tool for detecting specific molecular targets and combine molecular biology and nanotechnology aiming at modern imaging. We aimed at ligand-directed delivery with a suitable target-biomarker …
Publication
Vitamin D supplementation reduces some AT 1 -AA-induced downstream targets implicated in preeclampsia including hypertension
Autoantibodies to the ANG II type I receptor (AT1 -AA) are associated with preeclampsia (PE). We found that vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined whether the decrease in …
Publication
Stellate cells drive maturation of the entorhinal-hippocampal circuit
The neural representation of space relies on a network of entorhinal-hippocampal cell types with firing patterns tuned to different abstract features of the environment. To determine how this network is set up during early postnatal development, we …