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Original Article Differential Functional Deficits in Type 1 Versus Type 2 Diabetic Mice Models
Introduction: Types 1 and 2 diabetes have different causative mechanisms. Hence, different extent of cardiovascular, cognitive and auditory functions could be expected. Materials and methods: Body weight, blood glucose were measured in Wild type(WT), …
Publication
Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice
Assessment of right ventricular (RV) function in rodents is a challenge due to the complex RV anatomy and structure. Subsequently, the best characterization of RV function is achieved by accurate cardiovascular phenotyping, involving a combination of …
Publication
Targeting and modulating infarct macrophages with hemin formulated in designed lipid-based particles improves cardiac remodeling and function
Uncontrolled activation of pro-inflammatory macrophages after myocardial infarction (MI) accelerates adverse left ventricular (LV) remodeling and dysfunction. Hemin, an iron-containing porphyrin, activates heme oxygen- ase-1 (HO-1), an enzymewith …
Publication
Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction
Cardiac fibrosis is a common finding in patients with chronic kidney disease. Here, we investigate the cardio-renal effects of theracurmin, a novel formulation of the polyphenolic compound curcumin, in a rat model of chronic kidney disease. Briefly, …
Publication
Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction
Cardiac fibrosis is a common finding in patients with chronic kidney disease. Here, we investigate the cardio-renal effects of theracurmin, a novel formulation of the polyphenolic compound curcumin, in a rat model of chronic kidney disease. Briefly, …
Publication
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling
Increased production of methylglyoxal (MG) in vascular tissues is one of the causative factors for vascular remodeling in different subtypes of metabolic syndrome, including hypertension and insulin resistance. Fructose-induced upregulation of aldolase B …
Publication
Ultra High-frequency Ultrasound of Fascicles in the Median Nerve at the Wrist
Introduction: An ultra high-frequency (70 MHz) ultrasound device has recently been approved for human use. This study was conducted to determine if this device facilitates counting of fascicles within the median nerve at the wrist. Methods: Twenty healthy …
Publication
Dual-acting biofunctionalised scaffolds for applications in regenerative medicine
Off the shelf scaffolds for replacing ultra-small diameter vascular grafts are valuable for reconstruction of diseased or damaged vessels. The limitations for such grafts include optimal handling with ready availability of varied lengths of grafts, graft …
Publication
Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor 4α
Metformin, a small molecule antihyperglycaemic agent, is well-known as an AMP-activated protein kinase (AMPK) activator and protects against cardiac fibrosis. However, the underlying mechanisms remain elusive. Transforming growth factor-β1 (TGFβ1) is a …
Publication
Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart FailureCLINICAL PERSPECTIVE
BACKGROUND Hyaluronan (HA) is required for endothelial-to-mesenchymal transition and normal heart development in the mouse. Heart abnormalities in hyaluronidase 2 (HYAL2)-deficient (Hyal2(-)(/-) ) mice and humans suggested removal of HA is also important …