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Female Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II–Induced Abdominal Aortic AneurysmsClinical Perspective
Background—Abdominal aortic aneurysms (AAAs) are a deadly pathology with strong sexual dimorphism. Similar to humans, female mice exhibit far lower incidences of angiotensin II (AngII)-induced AAAs than males. In addition to sex hormones, the X and Y sex …
Publication
Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice
Background: T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes including repeated miscar- riages and fetal malformations. Despite the established association between placental insufficiency and poor mater- nal Th1-adaptability to the …
Publication
UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity
Doxorubicin (DOX) is an effective chemotherapeutic drug in the treatment of various types of cancers. However, its clinical application has been largely limited by potential development of cardiotoxicity. Previously we have shown that ultra-violet …
Publication
Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction
Inflammation is a known mediator of adverse ventricular remodeling aftermyocardial infarction (MI) thatmay lead to reduction of ejection fraction and subsequent heart failure. Berberine is a isoquinoline quarternary alka- loid from plants that has been …
Publication
Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc -deficient mice
OBJECTIVE We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD Using HFUS, we imaged embryos carrying loss of …
Publication
Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc -deficient mice
OBJECTIVE We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD Using HFUS, we imaged embryos carrying loss of …
Publication
Fetal Alcohol Exposure Alters Blood Flow and Neurological Responses to Transient Cerebral Ischemia in Adult Mice
Background: Prenatal alcohol exposure (PAE) can result in physical and neurocognitive deficits that are collectively termed “fetal alcohol spectrum disorders” (FASD). Although FASD is associated with lifelong intellectual disability, the mechanisms …
Publication
Elastase-2, an angiotensin II-generating enzyme, contributes to increased Ang II in resistance arteries of mice with myocardial infarction.
Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively …
Publication
Echocardiography-Guided Intramyocardial Injection Method in a Murine Model
Cardiac regenerative therapy has received attention as a potentially revolutionary approach for treating the damaged heart. The mouse model of myocardial infarction (MI) remains one of the most common tools for the evaluation of such new therapies. …
Publication
Challenging cardiac function post-spinal cord injury with dobutamine
There is general consensus that spinal cord injuries (SCI) above T6 result in altered sympathetic control of the heart,which negatively influences cardiac structure and function. To by-pass disrupted circuitry and investigate cardiac responses under …