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Crucial Role of miR-433 in Regulating Cardiac Fibrosis
Dysregulation of microRNAs has been implicated in many cardiovascular diseases including fibrosis. Here we report that miR-433 was consistently elevated in three models of heart disease with prominent cardiac fibrosis, and was enriched in fibroblasts …
Publication
Lack of immunoediting in murine pancreatic cancer reversed with neoantigen
In carcinogen-driven cancers, a high mutational burden results in neoepitopes that can be recognized immunologically. Such carcinogen-induced tumors may evade this immune response through “immunoediting,” whereby tumors adapt to immune pressure and escape …
Publication
Infarcted cardiac microenvironment may hinder cardiac lineage differentiation of human embryonic stem cells
Microenvironment regulates cell fate and function. In this study, we investigated the effects of the infarcted cardiac microenvironment on cardiac differentiation of human embryonic stem cells (hESCs). hESCs were intramyocardially transplanted into …
Publication
Visualization of haemophilic arthropathy in F8 −/− rats by ultrasonography and micro-computed tomography
A major complication of haemophilia is haemophilic arthropathy (HA), a debilitating disorder with an incompletely defined pathobiology. High-resolution imaging may provide new knowledge about onset and progression of HA, and thereby support identification …
Publication
PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis
Mutations in the PTRF/Cavin-1 gene cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. Additionally, long-QT syndrome and fatal cardiac arrhythmia are observed in patients with CGL4 who have homozygous PTRF/Cavin-1 …
Publication
TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice
First line treatment for recurrent and metastatic prostate cancer is androgen deprivation therapy (ADT).UseofADThasbeenincreasing infrequencyandduration, such that side effects increasingly impact patient quality of life. One of the most significant side …
Publication
Neonatal Arterial Morphology Is Related to Body Size in Abnormal Human Fetal GrowthCLINICAL PERSPECTIVE
BACKGROUND Restriction in fetal growth is associated with cardiovascular disease in adulthood. It is unclear whether abnormal intrauterine growth influences arterial morphology during the fetal or neonatal stage. The objective was to study the regional …
Publication
Biomimicking Platelet-Monocyte Interactions as a Novel Targeting Strategy for Heart Healing
In patients who survive myocardial infarction, many go on to develop congestive heart failure (CHF). Despite ongoing efforts to develop new approaches for postinfarction therapy, there are still no effective therapeutic options available to CHF patients. …
Publication
Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice
MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression of miR-221 induces heart failure in mice. The miR-222 and miR-221 share the same gene cluster, however, the role …
Publication
Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth through Disturbed Downstream TGF-β Signaling
Aneurysm-osteoarthritis syndrome characterized by unpredictable aortic aneurysm formation, is caused by SMAD3 mutations. Smad3 is part of the Smad2/3/4 transcription factor, essential for TGF-β-activated transcription. Although TGF-β-related gene …