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Publication
A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes.
Pathologic axillary lymph node (ALN) status is an important prognostic factor for staging breast cancer. Currently, status is determined by histopathology following surgical excision of sentinel lymph node(s), which is an invasive, time consuming, and …
Publication
PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
BACKGROUND: Intergenic variations on chromosome 4q25, close to the PITX2 transcription factor gene, are associated with atrial fibrillation (AF). We therefore tested whether adult hearts express PITX2 and whether variation in expression affects cardiac …
Publication
miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes
Acute myocardial infarction (MI) involves necrotic and apoptotic loss of cardiomyocytes. One strategy to salvage ischemic cardiomyocytes is to modulate gene expression to promote cell survival without disturbing normal cardiac function. MicroRNAs (miRNAs) …
Publication
Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice.
OBJECTIVES: We used a murine model of arrhythmogenic right ventricular cardiomyopathy (ARVC) to test whether reducing ventricular load prevents or slows development of this cardiomyopathy. BACKGROUND: At present, no therapy exists to slow progression of …
Publication
Evaluation of imaging technologies to correct for photon attenuation in the overlying tissue for in vivo bone strontium measurements.
The interpretation of measurements of bone strontium in vivo using energy dispersive x-ray fluorescence spectroscopy is presently hindered by overlying skin and soft-tissue absorption of the strontium x-rays. The use of imaging technologies to measure the …
Publication
Ultrasound-assisted non-viral gene transfer to the salivary glands
We report a non-viral gene transfer method utilizing ultrasound induced microbubble destruction to allow the uptake of plasmid gene transfer vectors to the cells of the mouse salivary gland. The Luciferase(Luc) reporter gene, driven by a …
Publication
Rubin H. Flocks and Colloidal Gold Treatments for Prostate Cancer
In the early 1950s, Rubin H. Flocks of the University of Iowa began to treat prostate cancer patients with colloidal gold (Au 198 ) therapy, evolving his technique over nearly 25 years in 1515 patients. We reviewed the long-term outcomes of Flocks' …
Publication
CPI-1189 Protects against TNBS-induced Colitis in a Rodent Model
Abstract: Nitrone-related therapeutics (NRTs) represents a new class of molecules that may be effective in treating inflammatory conditions. The goal of this study was to examine the effect of CPI- 1189 in a rat model of inflammatory bowel disease (IBD). …
Publication
Silver nanoplate contrast agents for in vivo molecular photoacoustic imaging.
Silver nanoplates are introduced as a new photoacoustic contrast agent that can be easily functionalized for molecular photoacoustic imaging in vivo. Methods are described for synthesis, functionalization, and stabilization of silver nanoplates using …
Publication
Noninvasive ultrasonic measurement of regional and local pulse-wave velocity in mice.
Mouse models of human disease are increasingly used to study the nature of cardiovascular diseases such as atherosclerosis. The pulse wave velocity (PWV) provides an indirect measure of arterial stiffness and can be useful for characterizing disease …