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Improved heart failure by Rhein lysinate is associated with p38MAPK pathway
The present study aimed to explore the role of Rhein lysinate (RHL) in neonatal rat ventricular myocytes (NRVMs) and congestive heart failure induced by co-arctation of the abdominal aorta. Male Sprague-Dawley rats were divided into 3 groups randomly: …
Publication
Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats
Cardiorespiratory fitness (CRF) inversely predicts cardiovascular (CV) mortal- ity and CRF is impaired in people with type 2 diabetes (T2D). Aerobic exer- cise training (ET) improves CRF and is associated with decreased risk of premature death in healthy …
Publication
Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer
Prostate Cancer (PCa) is the second most common and fifth cause of cancer-related mortality in males in Western Countries. The development of innovative tools for an early, more precise and noninvasive diagnosis is a medical need. Vascular volume (Vv) and …
Publication
Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis
Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention and treatment is thus of high priority. In a previous study, we have demonstrated a pathophysiologic relevance for the heterophilic …
Publication
Inhibition of prolyl hydroxylase domain proteins selectively enhances venous thrombus neovascularisation
BACKGROUND: Hypoxia within acute venous thrombi is thought to drive resolution through stabilisation of hypoxia inducible factor 1 alpha (HIF1α). Prolyl hydroxylase domain (PHD) isoforms are critical regulators of HIF1α stability. Non-selective inhibition …
Publication
Radioiodinated Pentixather for SPECT Imaging of the Chemokine Receptor CXCR4 Expression in Rat Myocardial Infarction/Reperfusion Models
The purpose of this study is to develop a specific CXCR4-targeting radioiodinated agent (125I/131I-pentixather) for single-photon emission computed tomography (SPECT) imaging of CXCR4 expression in myocardial infarction/reperfusion (MI/R) rat models. …
Publication
Endoglin‑targeted contrast‑enhanced ultrasound imaging in hepatoblastoma xenografts
Angiogenesis is required for the growth of hepa- toblastoma (HB). In the present study, an ultrasonic contrast agent, microbubbles (MB), was combined with an endoglin antibody, and then injected into nude mice with HB. This was conducted to detect …
Publication
Cardiovascular function in mice during normal pregnancy and in the absence of endothelial NO synthase
In humans, the increased cardiovascular demands of pregnancy are met by increases in cardiac output (CO), stroke volume (SV), plasma volume (PV), and cardiac and aortic inner dimensions and a concurrent decrease in arterial pressure that indicates a fall …
Publication
In vivo quantification of embryonic and placental growth during gestation in mice using micro-ultrasound.
BACKGROUND: Non-invasive micro-ultrasound was evaluated as a method to quantify intrauterine growth phenotypes in mice. Improved methods are required to accelerate research using genetically-altered mice to investigate the interactive roles of genes and …
Publication
The potential influence of diabetic history on peripheral blood flow in superficial skin
Vascular complication occurrence increases with the duration of diabetes. The present study compared the peripheral blood flow in superficial skin among subjects with a short or long history of diabetes as compared to a healthy control group. Thirty-two …