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Energy-Absorbing and Local Plasmonic Nanodiamond/Gold Nanocomposites for Sustained and Enhanced Photoacoustic Imaging
Photoacoustic (PA) imaging is a laser-mediated optical ultrasound-based visualization that allows imaging of optical energy absorbers in deep tissue, offering higher spatial resolution, compared with that of NIR fluorescence. To enhance a gold …
Publication
Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1
Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L-arginine depletion. Excessive arginase activity also can drive …
Publication
Deregulated Ca 2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin
Obscurins are cytoskeletal proteins with structural and regulatory roles encoded by OBSCN. Mutations in OBSCN are associated with the development of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Specifically, the R4344Q mutation …
Publication
MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents
An innovative approach for cardiac regeneration following injury is to induce endogenous cardiomyocyte (CM)cell cycle re-entry. In the present study, CMs from adult rat hearts were isolated and transfected with cel-miR-67 (control) and rno- miR-210. A …
Publication
In vivo MR-angiography for the assessment of aortic aneurysms in an experimental mouse model on a clinical MRI scanner: Comparison with high-frequency ultrasound and histology
Background MR-angiography currently represents one of the clinical reference-standards for the assessment of aortic-dimensions. For experimental research in mice, dedicated preclinical high-field MRI scanners are used in most studies. This type of MRI …
Publication
Folic acid prevents cardiac dysfunction and reduces myocardial fibrosis in a mouse model of high-fat diet-induced obesity
Background Folic acid (FA) is an antioxidant that can reduce reactive oxygen species generation and can blunt cardiac dysfunction during ischemia. We hypothesized that FA supplementation prevents cardiac fibrosis and cardiac dysfunction induced by …
Publication
Comparison of very-high-frequency ultrasound assessment of radial arterial wall layers after first and repeated transradial coronary procedures
BACKGROUND Transradial coronary procedure (TRP) traumatizes the radial artery (RA), especially resulting in changes to arterial wall morphology. This study explored the significance of the early onset of traumatic effects to wall layers of the RA …
Publication
Tumor Microenvironment Modulation by Cyclopamine Improved Photothermal Therapy of Biomimetic Gold Nanorods for Pancreatic Ductal Adenocarcinomas
Due to the rich stroma content and poor blood perfusion, pancreatic ductal adenocarcinoma (PDA) is a tough cancer that can hardly be effectively treated by chemo- therapeutic drugs. Tumor microenvironment modulation or advanced design of nanomedicine to …
Publication
Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts
Organogenesis during embryonic development oc- curs through the differentiation of progenitor cells. This process is extraordinarily accurate, but the mechanisms ensuring high fidelity are poorly under- stood. Coronary vessels of the mouse heart derive …
Publication
Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload
Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced …