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AHA 2026
American Heart Association - Scientific Sessions VISIT US AT BOOTH #2012! Are you presenting a poster using the Vevo? Let us promote your work!! Learn more here Join us in Chicago or virtually for this four-day experience, offering unmatched access to …
Publication
Promoting tumor antigen presentation unleashes therapeutic efficacy of Tgfbr2-deficient TCR-engineered T cells in pancreatic ductal adenocarcinoma
Background: Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with limited therapeutic options. Adoptive cell therapy (ACT) using tumor-reactive T cell receptor-engineered T cells (TCR-T) is a promising therapeutic modality for targeting PDA. …
Publication
Gut microbiota-derived caproic acid attenuates aging-associated arteriosclerosis
Aim: Aging is an irreversible primary risk factor for arteriosclerosis, causing high cardiovascular morbidity-mortality in the elderly via vascular remodeling and cellular senescence. Gut microbiota-derived short-chain fatty acids (SCFAs) exert …
Publication
Deciphering the Immune Landscape of Abdominal Aortic Aneurysm: A Machine Learning and Cross-Species Validated Multi-Omics Approach
Purpose: Abdominal aortic aneurysm (AAA) is characterized by chronic vascular inflammation and immune dysregulation. We aimed to prioritize tissue-associated diagnostic markers and candidate immune regulators using integrated transcriptomics, machine …
Publication
Improved quantification of photoacoustic biomarkers through residual-based noise masking
Spectroscopic photoacoustic (PA) imaging enables non-invasive, label-free estimation of in vivo biomarkers such as tissue oxygen saturation (SO2). Quantitative accuracy is limited by low signal-to-noise ratio (SNR) in deeper regions from fluence …
Publication
Photodynamic immune stimulation eradicates primary pigmented melanoma and induces long-lasting anti-tumor immunity
Background: Melanoma is highly aggressive with limited options in advanced disease. Photodynamic therapy (PDT) has shown poor efficacy in pigmented melanoma due to restricted light penetration and intrinsic ROS resistance. A novel approach is investigated …
Publication
Magnetothermal Wax Capsule for Localized Gastrointestinal Drug Delivery
Oral drug delivery to gastrointestinal (GI) lesions remains challenging, as current systems rely on physiological triggers such as pH, enzymes, and luminal pressure, which vary widely among patients. To address this, an ingestible capsule was developed to …
Publication
Dexmedetomidine enhances ultrasound-guided sciatic nerve block in rats by reducing perineural capillary permeability via RhoA/ROCK-MLC signaling
Dexmedetomidine (DEX) is widely used as an adjuvant to local anesthetics to prolong the duration of nerve block-induced analgesia. Despite its clinical efficacy, the precise mechanisms by which DEX enhances and extends analgesic effects remain …
Publication
Protocol to prepare PARPi-combined LIN28B siRNA nanoparticles and evaluate therapeutic efficacy of malignant ascites
Malignant serous effusion (MSE) is a life-threatening complication of advanced cancers with limited effective treatments. Here, we present a protocol for the preparation of LIN28B siRNA-loaded nanoparticles and their combination with PARP inhibition for …
Publication
Cocktail Therapy Combining SGLT2 Inhibitor, Entresto, and Adipose-Derived Mesenchymal Stem Cells Prevents Abdominal Aortic Aneurysmal Complication Syndrome in Rodents
Background: This study investigated whether triple combination therapy [dapagliflozin (DAPA) + sacubitril/valsartan (Entresto) + adipose-derived mesenchymal stem cells (ADMSCs)] offered additional benefits on preventing complication syndrome [defined as …