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Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer
ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC kinase family and has been shown to play a role in cell migration, ECM synthesis, stress-fiber assembly, and cell contraction. Increased ROCK expression has been …
Publication
PPAR γ Alleviates Right Ventricular Failure Secondary to Pulmonary Arterial Hypertension in Rats
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular hypertrophy (RVH) and failure. Peroxisome proliferator-activated receptor γ (PPARγ), a member of nuclear receptors, has been proved to …
Publication
Non-invasive monitoring of the therapeutic response in sorafenib-treated hepatocellular carcinoma based on photoacoustic imaging
PURPOSE: We investigated the changes of tissue oxygen saturation (sO2) in sorafenib-treated HCC (hepatocelluar carcinoma) mouse models using photoacoustic imaging (PI). MATERIALS AND METHODS: Nude mice, implanted with human HCC (HepG2-RFP) cells in the …
Publication
Photoacoustic Imaging for Noninvasive Periodontal Probing Depth Measurements
The periodontal probe is the gold standard tool for periodontal examinations, including probing depth measurements, but is limited by systematic and random errors. Here, we used photoacoustic ultrasound for high–spatial resolution imaging of probing …
Publication
Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy
Defective protein quality control (PQC) systems are implicated in multiple diseases. Molecular chaperones and co-chaperones play a central role in functioning PQC. Constant mechanical and metabolic stress in cardiomyocytes places great demand on the PQC …
Publication
Chronic exposure to electronic cigarette (E-cig) results in impaired cardiovascular function in mice
Proponents for electronic cigarettes(E-cigs) claim they are a safe alternative to smoking tobacco-based cigarettes,however little is known about the long-term effects of E-cig vapor exposure on vascular function.The purpose of this study was to determine …
Publication
Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II–induced hypertrophy
Lysyl oxidase (LOX) controls matrix remodeling, a key process that underlies cardiovascular diseases and heart failure; however, a lack of suitable animal models has limited our knowledge with regard to the contribution of LOX to cardiac dysfunction. …
Publication
Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy
Continuous contraction-relaxation cycles of the heart require strong and stable connections of cardiac myocytes (CMs) with the extracellular matrix (ECM) to preserve sarcolemmal integrity. CM attachment to the ECM is mediated by integrin complexes …
Publication
Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein
The mechanism for intermittent hypoxia (IH)-induced cardiomyopathy remains obscure. We reported the prevention of acute and chronic IH-induced cardiac damage by selective cardiac overexpression of metallothionein (MT). Herein we defined that MT-mediated …
Publication
Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia
Danqi pill (DQP) is a widely prescribed traditional Chinese medicine (TCM) in the treatment of cardiovascular diseases. The objective of this study is to systematically characterize altered gene expression pattern induced by myocardial ischemia (MI) in a …