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Adiponectin Determines Farnesoid X Receptor Agonism-Mediated Cardioprotection Against Post-Infarction Remodeling and Dysfunction
ptor superfamily that plays a critical regulatory role in cardiovascular physiology/pathology. However, the role of systemic FXR activation in the chronic phase in myocardial infarction (MI)-induced cardiac remodeling and dysfunction remains unclear. In …
Publication
(‑)‑Epicatechin protects against myocardial ischemia‑induced cardiac injury via activation of the PTEN/PI3K/AKT pathway
Flavonol (-)-epicatechin (EPI) is primarily contained in green tea (Camellia sinensis) and cocoa beans (Theobroma cacao), and has been demonstrated to be beneficial for the health of the cardiovascular system. However, the effect and the underlying …
Publication
Role of heat shock transcription factor 1(HSF1)-upregulated macrophage in ameliorating pressure overload-induced heart failure in mice
In order to explore the role of macrophages in HSF1-mediated alleviation of heart failure.Mice model of pressure overload-induced heart failure was established using transverse aortic constriction (TAC). Changes in cardiac function and morphology were …
Publication
Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice
Mouse models are extremely important in studying cardiac pathologies and related electrophysiology, but very few mouse ECG analysis programs are readily available. Therefore, a mouse ECG analysis algorithm was developed and validated. Surface ECG (lead …
Publication
3D-Printed Phantom Fabricated by Photopolymer Jetting Technology for High-Frequency Ultrasound Imaging
In the field of high-frequency ultrasound imaging (≥ 20 MHz), tools for characterizing the performance of imaging systems are lacking. Indeed, commercial phantoms are often inad- equate for this frequency range. The development of homemade phantoms on the …
Publication
Journal of Molecular and Cellular Cardiology Anti-oxidant e ff ect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy : Role of autophagy and c- kit pos CD45 neg CD31 neg cardiac stem cell activation
Doxorubicin (DOXO) is one of the most widely used antineoplastic drugs. Despite its highly beneficial effects against several malignancies, the clinical use of DOXO is often associated to cardiomyopathy that leads to congestive heart failure. Here we …
Publication
Short-Duration Swimming Exercise after Myocardial Infarction Attenuates Cardiac Dysfunction and Regulates Mitochondrial Quality Control in Aged Mice
Background . Exercise benefits to cardiac rehabilitation (CR) following stable myocardial infarction (MI). The suitable exercise duration for aged patients with coronary heart disease (CHD) remains controversial, and the underlying molecular mechanism is …
Publication
Andrographolide ameliorates diabetic cardiomyopathy in mice by blockage of oxidative damage and NF-κB-mediated inflammation
Andrographolide (Andro), a major bioactive component obtained from Andrographis paniculata Nees, has exerted wide antioxidant as well as cytoprotective properties. However, whether Andro treatment could retard the progress of diabetic cardiomyopathy (DCM) …
Publication
Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer
Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulates the …
Publication
Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum-infected erythrocytes (IEs) accumulate in the placenta by adhering …