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Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone’s Antifibrotic ActivityNovelty and Significance
Mineralocorticoid receptor antagonists (MRAs) reduce morbidity and mortality in chronic heart failure. Novel nonsteroidal MRAs are currently developed and need to be pharmacologically characterized in comparison to classical steroidal MRAs. A mouse model …
Publication
Strain imaging of the lateral collateral ligament using high frequency and conventional ultrasound imaging: An ex-vivo comparison
Recent first attempts of in situ ultrasound strain imaging in collateral ligaments encountered a number of challenges and illustrated a clear need for additional studies and more thorough validation of the avail- able strain imaging methods. Therefore, in …
Publication
DL-3-n-butylphthalide improves ventricular function, and prevents ventricular remodeling and arrhythmias in post-MI rats
DL-3-n-butylphthalide (NBP) is used in the treatment of ischemic stroke. It was demonstrated NBP also has a cardioprotective effect in acute myocardial infarction (MI) model. However, the chronic effects of NBP on ventricular function, remodeling, and …
Publication
Introducing a nested phase change agent with an acoustic response that depends on electric field: A candidate for myocardial perfusion imaging and drug delivery
We present a voltage-sensitive phase change agent comprising an aqueous emulsion of surfactant-coated liquid perfluorocarbon droplets nested within a negatively charged phospholipid bilayer. The sensitivity to voltage allows, via exposure to an electric …
Publication
Ablation of the stress protease OMA1 protects against heart failure in mice
Current therapies for heart failure vary depending on the root cause and stage of the disease. Acin-Perez et al . studied the molecular link between mitochondrial dysfunction and heart failure, focusing on OMA1, a protease involved in mitochondrial inner …
Publication
Ginsenoside Rb1 inhibits autophagy through regulation of Rho/ROCK and PI3K/mTOR pathways in a pressure-overload heart failure rat model
Objective This study was designed to explore the relationship between gin- senoside Rb1 (Grb1) and high-load heart failure (HF) in rats. Methods The parameters of cardiac systolic function (left ventricular posterior wall thickness (LVPWT), left …
Publication
CXCL8 hyper-signaling in the aortic abdominal aneurysm
There are indications for elevated CXCL8 levels in abdominal aortic aneurysm disease (AAA). CXCL8 is concurrently involved in neutrophil-mediated inflammation and angiogenesis, two prominent and distinctive characteristics of AAA. As such we considered an …
Publication
MiR-124 aggravates failing hearts by suppressing CD151-facilitated angiogenesis in heart
Heart failure (HF) is the final common pathway of various cardiovascular diseases. Although it is well documented that reduction of cardiac angiogenesis contributes to the progression from adaptive cardiac hypertrophy to HF, the molecular mechanisms …
Publication
Photoacoustic imaging of synovial tissue hypoxia in experimental post-traumatic osteoarthritis.
OBJECTIVES: This pilot study aimed to investigate the feasibility of non-invasively assessing synovial tissue hypoxia in vivo using photoacoustic (PA) imaging in a post-traumatic osteoarthritis model and explore its correlation with OA severity. METHODS: …
Publication
Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers
RATIONALE: Diaphragm weakness in critically ill patients prolongs ventilator dependency and duration of hospital stay, and increases mortality and health care costs. The mechanisms underlying diaphragm weakness include cross-sectional fiber atrophy and …