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Molecular Ultrasound Imaging Depicts the Modulation of Tumor Angiogenesis by Acetylsalicylic Acid
Acetylsalicylic acid (ASA) is a well-established drug for heart attack and stroke prophylaxis. Furthermore, numerous studies have reported an anti-carcinogenic effect, but its exact mechanism is still unknown. Here, we applied VEGFR-2-targeted molecular …
Publication
Visual inertial odometry enabled 3D ultrasound and photoacoustic imaging
There is an increasing need for 3D ultrasound and photoacoustic (USPA) imaging technology for real-time monitoring of dynamic changes in vasculature or molecular markers in various malignancies. Current 3D USPA systems utilize expensive 3D transducer …
Publication
Estimation of Mouse Carotid Arterial Wall Shear Stress Using High-Frequency Ultrasound Imaging
Wall shear stress (WSS) is a crucial hemodynamic factor that promotes atherosclerosis (plaque) development in arteries; although the relationship between WSS and arterial atherosclerosis has been explored in many animal studies, it is not fully …
Publication
CARMA3 deficiency aggravates angiotensin II-induced abdominal aortic aneurysms development interacting between endoplasmic reticulum and mitochondria
Background: Abdominal aortic aneurysm (AAA) is life threatening and associated with vascular walls’ chronic inflammation. However, a detailed understanding of the underlying mechanisms is yet to be elucidated. CARMA3 assembles the CARMA3‐BCL10‐MALT1 (CBM) …
Publication
Nonspherical ultrasound microbubbles
Surface tension provides microbubbles (MB) with a perfect spherical shape. Here, we demonstrate that MB can be engineered to be nonspherical, endowing them with unique features for biomedical applications. Anisotropic MB were generated via …
Publication
Peritoneal pre-conditioning impacts long-term vascular graft patency and remodeling
ABSTRACT There are questions about how well small-animal models for tissue-engineered vascular grafts (TEVGs) translate to clinical patients. Most TEVG studies used grafting times ≤6 months where conduits from generally biocom- patible materials like …
Publication
Tissue factor as a novel diagnostic target for early detection of ovarian cancer using ultrasound microbubbles
Introduction: Ovarian cancer (OC) is the deadliest gynecologic malignancy, with an overall 5-year survival rate of less than 30%. The existing paradigm for OC detection involves a serum marker, CA125, and ultrasound examination, neither of which is …
Publication
Stimulating Antitumoral Immunity by Percutaneous Cryoablation and Combination Immunoadjuvant Therapy in a Murine Model of Hepatocellular Carcinoma.
PURPOSE To test the hypothesis that antitumoral immunity can be induced after cryoablation of hepatocellular carcinoma (HCC) through co-administration of the immunostimulant CpG and an immune checkpoint (PD-1) inhibitor. METHODS 63 immunocompetent …
Publication
Hybrid photoacoustic and fast super-resolution ultrasound imaging
The combination of photoacoustic (PA) imaging and ultrasound localization microscopy (ULM) with microbubbles has great potential in various fields such as oncology, neuroscience, nephrology, and immunology. Here we developed an interleaved PA/fast ULM …
Publication
Nanomaterial-decorated micromotors for enhanced photoacoustic imaging
Micro-and nanorobots have the potential to perform non-invasive drug delivery, sensing, and surgery in living organisms, with the aid of diverse medical imaging techniques. To perform such actions, microrobots require high spatiotemporal resolution …