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Feasibility and precision of transcutaneous very-high resolution ultrasound for quantification of arterial structures in human neonates – Comparison with conventional high resolution vascular ultrasound imaging
Background: Non-invasive transcutaneous very-high resolution ultrasound (VHRU, 25-55MHz) has recently been developed to quantify superficial vascular structures in humans. The performance of the method has yet not been evaluated invivo in neonates. The …
Publication
Semi-automatic border detection software for the quantification of arterial lumen, intima-media and adventitia layer thickness with very-high resolution ultrasound
Background: The aim was to evaluate the accuracy, precision and feasibility of semi-automatic border detection software (AMS) in comparison to manual electronic calipers (EC) in the analysis of arterial images obtained with transcutaneous very-high …
Publication
ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted myocardium in vivo
Reactive oxygen species (ROS) play an important role in the pathogenesis of numerous diseases including atherosclerosis, diabetes, inflammation and myocardial infarction (MI). In this study, a ROS-responsive biodegradable elastomeric polyurethane …
Publication
Ablation of the N terminus of cardiac essential light chain promotes the super‐relaxed state of myosin and counteracts hypercontractility in hypertrophic cardiomyopathy mutant mice
In this study, we focus on the molecular mechanisms associated with the A57G (Ala57-to-Gly57) mutation in myosin essential light chains (ELCs), found to cause hypertrophic cardiomyopathy (HCM) in humans and in mice. Specifically, we studied the effects of …
Publication
Severe hypoglycemia exacerbates myocardial dysfunction and metabolic remodeling in diabetic mice
Although several studies have revealed that adverse cardiovascular events in diabetic patients are closely associated with severe hypoglycemia (SH), the causal relationship and related mechanisms remain unclear. This study aims to investigate whether SH …
Publication
A spontaneously metastatic model of bladder cancer: imaging characterization
Background: Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic …
Publication
<scp>CD74</scp> knockout protects against LPS‐induced myocardial contractile dysfunction through <scp>AMPK‐Skp2‐SUV39H1</scp> ‐mediated demethylation of <scp>BCLB</scp>
Background and Purpose: Lipopolysaccharides (LPS), an outer membrane component of Gram-negative bacteria, triggers myocardial anomalies in sepsis. Recent findings indicated a role for inflammatory cytokine MIF and its receptor, CD74, in septic organ …
Publication
Ultra - small Pyropheophorbide - a Nanodots for Near - infrared Fluorescence/Photoacoustic Imaging-guided Photodynamic Therapy
Rationale: Nanoparticles (NPs) that are rapidly eliminated from the body offer great potential in clinical test. Renal excretion of small particles is preferable over other clearance pathways to minimize potential toxicity. Thus, there is a significant …
Publication
Validation of ultrasound biomicroscopy for the assessment of xenogeneic testis tissue grafts and cell implants in recipient mice
Background: Subcutaneous grafting/implantation of neonatal testis tissue/cells from diverse donor species into recipient mice can be used as an in vivo model to study testis development, spermatogenesis, and steroidogenesis. Ultrasound biomicros- copy …
Publication
Exercise preconditioning protects against acute cardiac injury induced by lipopolysaccharide through general control nonderepressible 2 kinase
Exercise preconditioning may protect against cardiac injury induced by lipopolysaccharide (LPS), but the mechanism is unresolved. The aim of this study is to explore whether the general control nonderepressible 2 (GCN2) kinase gene is associated with the …