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LCZ696 (sacubitril/valsartan) inhibits pulmonary hypertension induced right ventricular remodeling by targeting pyruvate dehydrogenase kinase 4
Background: Right ventricular (RV) function is a major prognostic factor in patients with cardiopulmonary disease. Effective medical therapies are available for left heart failure, but they are usually less effective or even ineffective in right heart …
Publication
Treatment of hepatocellular carcinoma by multimodal in situ vaccination using cryoablation and a plant virus immunostimulant
To test the hypothesis that cryoablation combined with intratumoral immunomodulating nanoparticles from cowpea mosaic virus (CPMV) as an in situ vaccination approach induces systemic antitumoral immunity in a murine model of hepatocellular carcinoma …
Publication
Nonspherical ultrasound microbubbles
Surface tension provides microbubbles (MB) with a perfect spherical shape. Here, we demonstrate that MB can be engineered to be nonspherical, endowing them with unique features for biomedical applications. Anisotropic MB were generated via …
Publication
47-of Natural Medicines
[ABSTRACT] Background: Acute lung injury (ALI) is a critical illness in clinical with high incidence and mortality, and is characterized by inflammatory injury to the lung endothelial and epithelial barriers. Furthermore, safe and effective drugs for the …
Publication
Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms
Objective: Metformin treatment attenuates experimental abdominal aortic aneurysm (AAA) formation, as well as reduces clinical AAA diameter enlargement in patients with diabetes. The mechanisms of metformin-mediated aneurysm suppression, and its efficacy …
Publication
Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be avoided?
Noninvasive imaging exploration of phacomatosis pigmentokeratotica using high‐frequency ultrasound and optical coherence tomography: Can biopsy of PPK patients be …
Publication
Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest
Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest …
Publication
Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model
Despite aggressive therapeutic regimens, glioblastoma (GBM) represents a deadly brain tumor with significant aggressiveness, radioresistance and chemoresistance, leading to dismal prognosis. Hypoxic microenvironment, which characterizes GBM, is associated …
Publication
Ultra-High Frequency Ultrasound Imaging of Bowel Wall in Hirschsprung’s Disease—Correlation and Agreement Analyses of Histoanatomy
Hirschsprung’s disease (HD) is characterized by aganglionosis in the bowel wall, requiring resection. Ultra-high frequency ultrasound (UHFUS) imaging of the bowel wall has been suggested to be an instantaneous method of deciding resection length. The aim …
Publication
A self-charging salt water battery for antitumor therapy
Implantable devices on the tumor tissue as a local treatment are able to work in situ, which minimizes systemic toxicities and adverse effects. Here, we demonstrated an implantable self-charging battery that can regulate tumor microenvironment …