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Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy
Sudden unexpected death in epilepsy (SUDEP) is a significant cause of premature seizure-related death. An association between SUDEP and cardiac remodeling has been suggested. However, whether SUDEP is a direct consequence of acute or recurrent seizures is …
Publication
Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression
The neonatal mammalian heart is capable of regeneration for a brief window of time after birth. However, this regenerative capacity is lost within the first week of life, which coincides with a postnatal shift from anaerobic glycolysis to mitochondrial …
Publication
Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction
Insulin resistance increases patients’ risk of developing type 2 diabetes (T2D), non-alcoholic steatohepatitis (NASH) and a host of other comorbidities including cardiovascular disease and cancer. At the molecular level, insulin exerts its function …
Publication
MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway
Background: Accumulating evidence has revealed the roles of microRNAs (miRs) in sepsis, hence, the aim of the present study was to investigate whether miR-208a-5p affects sepsis whilst attempting to elucidate the mechanisms by which the suppressors of …
Publication
Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet
Background: Obesity, hypertension and prediabetes contribute greatly to coronary artery disease, heart failure and vascular events, and are the leading cause of mortality and morbidity in developed societies. Salt sensitivity exacerbates endothelial …
Publication
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
The sarco-endoplasmic reticulum (SR/ER) plays an important role in the development and progression of many heart diseases. However, many aspects of its structural organization remain largely unknown, particularly in cells with a highly differentiated …
Publication
Histamine deficiency facilitates coronary microthrombosis after myocardial infarction by increasing neutrophil‐platelet interactions
Neutrophil-platelet interactions are responsible for thrombosis as well as inflammatory responses following acute myocardial infarction (AMI). While histamine has been shown to play a crucial role in many physiological and pathological processes, its …
Publication
Thrombospondin‐1 mediates Drp‐1 signaling following ischemia reperfusion in the aging heart
Background: Ischemia reperfusion (IR) injury leads to activation of dynamin-re- lated protein (Drp-1), causing mitochondrial fission and generation of reactive oxy- gen species (ROS), but the molecular mechanisms that activate Drp-1 are not known. The …
Publication
Adenosine A2A receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT
Hypertensive cardiac remodeling is a constellation of abnormalities that includes cardiomyocyte hypertrophy and death and tissue fibrosis. Adenosine is a long-known vasodilator, through interacting with its four cell surface receptor subtypes in …
Publication
Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic
Chelating Cu from tumors has been verified as an effective and promising strategy for cancer therapy through antiangiogenesis. However, systematic removal Cu by injecting with Cu chelators will result unavoidable side effects, since Cu is indispensable to …