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The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice
Background: Aging is associated with metabolic and structural changes causing heart failure with preserved ejection fraction (HFpEF). Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging-related inflammation. Objective: We sought to …
Publication
Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure
Background: Chronic heart failure (CHF) is associated with redox imbalance. Downregulation of Nrf2 (nuclear factor [erythroid-derived 2]-like 2) plays important roles in disrupting myocardial redox homeostasis and mediating sympathetic nerve activity in …
Publication
Comparative assessment of coronary physiology using transthoracic pulsed-wave Doppler and myocardial contrast echocardiography in rats
BACKGROUND: Coronary physiology assessment in rodents by ultrasound is an excellent noninvasive and easy to perform technique, including pulsed-wave Doppler (PWD) and myocardial contrast echocardiography (MCE). Both techniques and the corresponding …
Publication
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell-cell adhesion. Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of right ventricular predominance. Here, we use a range of …
Publication
Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2
Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the …
Publication
Overexpression of Skeletal Muscle Nrf2 Protects Against Aging‐Associated Dysfunction in Skeletal Muscle and Heart
The nuclear factor erythroid 2–related factor 2 (Nrf2) is a master transcription factor governing hundreds of genes coding proteins involved in anti-oxidation, anti-inflammation, detoxification, and metabolism. Using a model of tissue-specific deletion of …
Publication
Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats
Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the mechanism is unclear. Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) following the disassociation with its repressor Keap1 under oxidative stress …
Publication
Nuclear Factor Erythroid 2–Related Factor 2 Activation and Burn-Induced Cardiac Dysfunction
Background: Our previous studies have found that burn injury induces cardiac dysfunction through interruption of the antioxidant-response element (ARE) pathway in cardiac mitochondria. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator …
Publication
Melatonin alleviates myocardial ischemia-reperfusion injury in mice by inhibiting inflammatory response via activating Nrf2 signaling
Objective: To investigate the protective effect of melatonin against myocardial ischemia-reperfusion (IR) injury in mice and the role of Nrf2 signaling in mediating this effect. Methods: C57/bl6 mice were randomized into sham-operated group(Sham), IR …
Publication
3D Ultrasound-Guided Photoacoustic Imaging to Monitor the Effects of Suboptimal Tyrosine Kinase Inhibitor Therapy in Pancreatic Tumors
Pancreatic cancer is a disease with an incredibly poor survival rate. As only about 20% of patients are eligible for surgical resection, neoadjuvant treatments that can relieve symptoms and shrink tumors for surgical resection become critical. Many forms …