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Renal Tissue PO 2 Sensing During Acute Hemodilution is Dependent on the Diluent.
The mechanism by which the kidney senses changes in hemoglobin concentration (Hb) may inform decisions regarding the optimal fluid for intravascular volume resuscitation in critical care settings where starch solution may be nephrotoxic. We hypothesized …
Publication
Luteolin attenuates sepsis‑induced myocardial injury by enhancing autophagy in mice
Sepsis-induced cardiomyopathy (SIc) is a compli- cation of severe sepsis and septic shock characterized by an invertible myocardial depression. This study sought to explore the potential effects and mechanism of luteolin, a flavonoid polyphenolic …
Publication
Inhibition of erythropoietin‐producing hepatoma receptor B4 (EphB4) signaling suppresses the vascularization and growth of endometriotic lesions
Background and Purpose: The development of endometriotic lesions is crucially dependent on the formation of new blood vessels. In the present study, we analyzed whether this process is regulated by erythropoietin-producing hepatoma receptor B4 (EphB4) …
Publication
LncRNA Tincr regulates PKCɛ expression in a miR-31-5p-dependent manner in cardiomyocyte hypertrophy
Cardiomyocyte hypertrophy is a fatal factor in heart disease resulting in heart failure and even mortality. Although many studies have been focusing on the pathogenesis of cardiomyocyte hypertrophy, the exact molecular mechanisms are still unexclusive. In …
Publication
Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome
Cardiopoietic stem cells have reached advanced clinical testing for ischemic heart failure. To profile their molecular influence on recipient hearts, systems proteomics was here applied in a chronic model of infarction randomized with and without human …
Publication
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling
The elevated expression of poly(ADP-ribose) polymerase-1 (PARP1) and increased PARP1 activity, namely, poly(ADP- ribosyl)ation (PARylation), have been observed in cardiac remodeling, leading to extreme energy consumption and myocardial damage. However, …
Publication
Berberine alleviates pulmonary hypertension through Trx1 and β-catenin signaling pathways in pulmonary artery smooth muscle cells
Pulmonary arterial hypertension (PAH) is closely associated with profound vascular remodeling, especially pulmonary arterial medial hypertrophy and muscularization, due to aberrant proliferation of pulmonary artery smooth muscle cells (PASMCs). Berberine, …
Publication
Photoacoustic Imaging-Trackable Magnetic Microswimmers for Pathogenic Bacterial Infection Treatment
Micro/nanorobots have been extensively ex- plored as a tetherless small-scale robotic biodevice to perform minimally invasive interventions in hard-to-reach regions. Despite the emergence of versatile micro/nanorobots in recent years, matched in vivo …
Publication
A durable murine model of spleen transplantation with arterial and venous anastomoses
The spleen is a large lymphoid organ located in the abdomen that filters blood and regulates the immune system. The extent of mobilization of splenic immune cells to peripheral tissues in health and disease, however, remains poorly understood. This is …
Publication
The therapeutic impact of human neonatal BMSC in a right ventricular pressure overload model in mice
OBJECTIVE: To determine the impact of donor age on the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSCs) in treating adverse remodeling as the result of right ventricle (RV) pressure overload. METHODS: BMSCs were isolated from …