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Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment
The development of novel anticancer therapies warrants the parallel development of biomarkers that can quantify their effectiveness. Photoacoustic imaging has the potential to measure changes in tumor vasculature during treatment. Establishing the …
Publication
Pyruvate kinase M2 activation protects against the proliferation and migration of pulmonary artery smooth muscle cells
Pyruvate kinase M2 (PKM2), which is encoded by PKM, is a ubiquitously expressed intracellular protein and is associated with proliferation cell phenotype. In PAH patients and PAH models, we found higher levels of PKM2 tyrosine 105 phosphorylation …
Publication
GSK2593074A blocks progression of existing abdominal aortic dilation
Objective: Receptor interacting proteins kinase 1 and 3 (RIPK1 and RIPK3) have been shown to play essential roles in the pathogenesis of abdominal aortic aneurysms (AAAs) by mediating necroptosis and inflammation. We previously discovered a small …
Publication
miR-125 family regulates XIRP1 and FIH in response to myocardial infarction
MicroRNAs (miRNAs) are powerful regulators of protein expression. Many play important roles in cardiac development and disease. While several miRNAs and targets have been well characterized, the abundance of miRNAs and the numerous potential targets for …
Publication
Sevoflurane up-regulates microRNA-204 to ameliorate myocardial ischemia/reperfusion injury in mice by suppressing Cotl1
Objective: The inhaled sevoflurane (sevo) is known to protect against myocardial ischemia/reperfusion (I/R) injury (MIRI), in which the functions of microRNAs (miRNAs) have been uncovered. However, the effect of sevo regulating miR-204 on this disease …
Publication
Motivational Interview to improve vascular health in Adolescents with poorly controlled type 1 Diabetes (MIAD): a randomized controlled trial
INTRODUCTION: We studied if motivational interviewing (MI) added to standard educational care (SEC) improves vascular health in adolescents with poorly controlled type 1 diabetes. RESEARCH DESIGN AND METHODS: 47 adolescents with type 1 diabetes of at …
Publication
Ultrasound Imaging of Nevus Sebaceous of Jadassohn
Nevus sebaceous of Jadassohn (NSJ) is a cutaneous hamartoma commonly found in the scalp and face and more frequent in children. Clinically, it presents as a yellowish and hairless plaque. In later stages, the NSJ can develop secondary tumors, including …
Publication
A mouse model of stenosis distal to an arteriovenous fistula recapitulates human central venous stenosis
Objective: Central venous stenosis (CVS) is a major cause of arteriovenous fistula (AVF) failure. However, central veins are relatively inaccessible to study with conventional Doppler ultrasound methods. To understand mechanisms underlying AVF failure …
Publication
Mir-125 family regulates xirp1 and fih in response to myocardial infarction
miR-125 family regulates XIRP1 and FIH in response to myocardial infarction. Physiol Genomics 52: 358–368, 2020. First published July 27, 2020; doi:10.1152/physiolgenom-ics.00041.2020.—MicroRNAs (miRNAs) are powerful regulators of protein expression. Many …
Publication
Screening for in-vivo regional contractile defaults to predict the delayed doxorubicin cardiotoxicity in Juvenile Rat
Anthracyclines are key chemotherapeutic agents used in various adult and pediatric cancers, however, their clinical use is limited due to possible congestive heart failure (HF) caused by acute and irreversible cardiotoxicity. Currently, there is no method …