Aim: To investigate the clinical feasibility of ultra-high-frequency abdominal ultrasound (UHFUS) scans of preterm and term infants. Methods: Prospectively, 19 healthy term newborn infants were examined with conventional ultrasound (CUS) (Toshiba, Aplio …

Background and Aim: Lung cancer remains a leading cause of global mortality, necessitating robust animal models for research into its mechanisms and therapeutic options. This study aimed to develop and validate a novel lung cancer mouse model using the …

Background: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors. Specifically, PHGDH expression is dynamically regulated during …

Echocardiography is the most primary clinical modality for dynamic cardiac imaging. However, the vigorous motion of myocardial tissue inherently causes inevitable signal aliasing between blood flow and myocardial tissue in traditional Doppler ultrasound …

Mechanistic insight into plasticizer di-(2-ethylhexyl) phthalate as an environmental hazard for abdominal aortic aneurysm: Evidence from in vitro and in vivo …

The effect of presence and location of microcalcifications on atherosclerotic plaque rupture: A tissue-engineering approach …

African turquoise killifish (Nothobranchius furzeri) is the shortest-lived vertebrate that can be bred in captivity, making it an ideal model organism for aging studies. However, whether the animal can be used for studying cardiac aging and whether …

Epidemiological studies show that heart failure often leads to kidney dysfunction, known as cardio-renal syndrome (CRS). Elevated central venous pressure, rather than low cardiac output, strongly correlates with worsening renal function and is …

Activating mutations of Src homology-2 domain-containing protein tyrosine phosphatase-2 (Shp2) cause multiple childhood conditions for which there is an unmet therapeutic need, including juvenile myelomonocytic leukemia (JMML) and Noonan syndrome. SFX-01, …

Macrophage pyroptosis has been identified as a critical pathological mechanism in inflammation-related athero-sclerosis (AS). In this work, we have demonstrated that Zn 2+ features the strongest anti-inflammatory performance by screening 10 representative …