3D volumes drawn around the murine left kidney (in yellow) and associated tumors (in pink and blue). … … 3D Volume of the Left Kidney with …

Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incom- pletely understood. Here we show that GIPR agonism did not …

Abdominal aortic aneurysm (AAA) is a fatal disease that is associated with chronic inflammation in the vessel wall. Cortistatin is implicated in inflammation, vascular smooth muscle cell migration and other cardiovascular pathologies. But, the …

Therapeutic strategies that increase hydrogen sulfide (H2S) or nitric oxide (NO) are cytoprotective in various models of cardiovascular injury. However, the nature of interaction between H2S and NO in heart failure and the underlying mechanisms for the …

Background: Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease in the presence of chronic kidney disease due to an accumulation of …

Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we …

Ultrasound guided injection into the developing spinal cord in a mouse embryo. … … Injection into the Embryonic Spinal Cord …

Background. Levels of fibroblast growth factor 23 (FGF23) increase early in chronic kidney disease (CKD) and are inde- pendently associated with left ventricular hypertrophy (LVH), heart failure and death. Experimental models of CKD with ele- vated FGF23 …

The poor drug delivery to primary and metastatic tumors of breast cancer remains a great challenge for effective antimetastasis therapy. Herein, a tumor microenvironment-activated cabazitaxel micelles decorated with legumain-specific melittin (TCM-legM) …

Myocardial ischemia/reperfusion (I/R) still have high morbidity and mortality worldwide. Platelet activating factor (PAF) is a potent phospholipid regulator of inflammation. PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear …