Activating mutations of Src homology-2 domain-containing protein tyrosine phosphatase-2 (Shp2) cause multiple childhood conditions for which there is an unmet therapeutic need, including juvenile myelomonocytic leukemia (JMML) and Noonan syndrome. SFX-01, …

Macrophage pyroptosis has been identified as a critical pathological mechanism in inflammation-related athero-sclerosis (AS). In this work, we have demonstrated that Zn 2+ features the strongest anti-inflammatory performance by screening 10 representative …

The glycometabolism and enzyme activity of Cu2MnS3-x-PEG/glucose oxidase (MCPG) achieve a cascade catalytic reaction, continuously replenishing the deficient H2O2 and O2 and inducing adequate reactive oxygen species supply. Density functional theory …

Non-muscle-invasive bladder cancer (NMIBC) can progress to muscle-invasive disease, with transurethral resection followed by Bacillus Calmette-Guérin (BCG) immunotherapy reducing this risk. Effective immunotherapies for BCG-resistant NMIBC are lacking. …

Renal congestion is a key factor in renal dysfunction associated with heart failure. We previously reported that renal congestion worsened renal ischemia-reperfusion in a murine model. However, its impact on sepsis-associated acute kidney injury (SA-AKI), …

Radiotherapy remains a cornerstone in metastatic cancer treatment but is often hindered by tumor hypoxia and radioresistance. Gold nanorods (AuNRs) offer promise in enhancing radiotherapy through hyperthermia, yet their clinical impact is limited by poor …

Depth-dependent fluence compensation without a priori knowledge of tissue composition for quantitative ultrasound-guided photoacoustic …

This is the first investigation to show that the angiotensin II type 2 receptor (AT2R) attenuates aging-associated arterial stiffness in middle-aged female mice. The AT2R also attenuates arterial stiffness in young female and male mice, but there are …

Renal fibrosis, a crucial pathological process in chronic kidney disease, requires early precise diagnosis to delay renal failure. Traditional ultrasound has limitations in sensitivity and specificity. In this study, SF 6 -loaded phospholipid nanobubbles …

Extending the transmit and receive bandwidths of dual-frequency transducers towards clinical acoustic angiography: in vitro and in vivo …