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AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling
AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling …
Publication
Kruppel-like factor 10 protects against acute viral myocarditis by negatively regulating cardiac MCP-1 expression
Viral myocarditis (VMC) is a cardiac disease associated with myocardial inflammation and injury induced by virus infection. Cardiomyocytes have recently been regarded as key players in eliciting and modulating inflammation within the myocardium. …
Publication
Dual-mode contrast agents with rgd-modified polymer for tumour-targeted us/nirf imaging
Background: Cancer diagnosis and treatment during the early stages of disease remain extremely challenging clinical tasks. The development of effective multimode contrast agents could greatly facilitate the early detection of cancer. Materials and …
Publication
Scattering Signatures of Normal versus Abnormal Livers with Support Vector Machine Classification
Fifty years of research on the nature of backscatter from tissues has resulted in a number of promising diagnostic parameters. We recently introduced two analyses tied directly to the biophysics of ultrasound scattering: the H-scan, based on a matched …
Publication
An overview of methods for cardiac rhythm detection in zebrafish
The heart is the most important muscular organ of the cardiovascular system, which pumps blood and circulates, supplying oxygen and nutrients to peripheral tissues. Zebrafish have been widely explored in cardiotoxicity research. For example, the zebrafish …
Publication
Gas vesicle isolated from microorganisms to act as ultrasound contrast agent
Purpose: Ultrasound contrast agent (UCA), used to enhance the contrast in ultrasonography, consists of microbubbles filled with an inert gas and encapsulated with a protein or a lipidic-stabilize membrane. The UCAs are able to resonate when exposed to …
Publication
Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia
Obscurin comprises a family of giant modular proteins that play key structural and regulatory roles in striated muscles. Immunoglobulin domains 58/59 (Ig58/59) of obscurin mediate binding to essential modulators of muscle structure and function, including …
Publication
Radial Motion Estimation of Myocardium in Rats with Myocardial Infarction: A Hybrid Method of FNCCGLAM and Polar Transformation
Ultrasound elastography is a novel approach of evaluating regional myocardial systolic function and detecting infarcted area. This study aims to evaluate the radial motion of myocardial infarction (MI) area in left ventricular parasternal short axis …
Publication
Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension
Pulmonary arterial hypertension is a severe and progressive disease characterized by a pulmonary vascular remodeling process with expansion of collateral endothelial cells and total vessel occlusion. Endothelial cells are believed to be at the forefront …
Publication
Exercise training delays cardiac remodeling in a mouse model of cancer cachexia
Aims: We aimed to investigate the impact of cancer cachexia and previous aerobic exercise training (AET) on cardiac function and structure in tumor bearing mice. Main methods: Colon adenocarcinoma cells 26 (CT26) were subcutaneously injected in BALB/c …