The excessive inflammation triggered by damage-associated molecular patterns (DAMPs) after myocardial infarction (MI) is responsible for the development of cardiac dysfunction and adverse remodeling, while the mechanisms by which inflammation is fine …

Background. Peptide infusions of the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3) have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuited for chronic …

Patients with acute myocardial infarction receive a P2Y12 receptor antagonist prior to reperfusion, a treatment that has reduced, but not eliminated, mortality, or heart failure. We tested whether the caspase-1 inhibitor VX-765 given at reperfu- sion (a …

The present study aimed to explore the role of Rhein lysinate (RHL) in neonatal rat ventricular myocytes (NRVMs) and congestive heart failure induced by co-arctation of the abdominal aorta. Male Sprague-Dawley rats were divided into 3 groups randomly: …

Cardiorespiratory fitness (CRF) inversely predicts cardiovascular (CV) mortal- ity and CRF is impaired in people with type 2 diabetes (T2D). Aerobic exer- cise training (ET) improves CRF and is associated with decreased risk of premature death in healthy …

Prostate Cancer (PCa) is the second most common and fifth cause of cancer-related mortality in males in Western Countries. The development of innovative tools for an early, more precise and noninvasive diagnosis is a medical need. Vascular volume (Vv) and …

Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention and treatment is thus of high priority. In a previous study, we have demonstrated a pathophysiologic relevance for the heterophilic …

BACKGROUND: Hypoxia within acute venous thrombi is thought to drive resolution through stabilisation of hypoxia inducible factor 1 alpha (HIF1α). Prolyl hydroxylase domain (PHD) isoforms are critical regulators of HIF1α stability. Non-selective inhibition …

The purpose of this study is to develop a specific CXCR4-targeting radioiodinated agent (125I/131I-pentixather) for single-photon emission computed tomography (SPECT) imaging of CXCR4 expression in myocardial infarction/reperfusion (MI/R) rat models. …

Angiogenesis is required for the growth of hepa- toblastoma (HB). In the present study, an ultrasonic contrast agent, microbubbles (MB), was combined with an endoglin antibody, and then injected into nude mice with HB. This was conducted to detect …