Background: T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes including repeated miscar- riages and fetal malformations. Despite the established association between placental insufficiency and poor mater- nal Th1-adaptability to the …

Doxorubicin (DOX) is an effective chemotherapeutic drug in the treatment of various types of cancers. However, its clinical application has been largely limited by potential development of cardiotoxicity. Previously we have shown that ultra-violet …

Inflammation is a known mediator of adverse ventricular remodeling aftermyocardial infarction (MI) thatmay lead to reduction of ejection fraction and subsequent heart failure. Berberine is a isoquinoline quarternary alka- loid from plants that has been …

OBJECTIVE We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD Using HFUS, we imaged embryos carrying loss of …

OBJECTIVE We used non-invasive high frequency ultrasound (HFUS) imaging to investigate embryonic brain development in a mouse model for neural tube defects (NTDs) and Non-Ketotic Hyperglycinemia (NKH). METHOD Using HFUS, we imaged embryos carrying loss of …

Background: Prenatal alcohol exposure (PAE) can result in physical and neurocognitive deficits that are collectively termed “fetal alcohol spectrum disorders” (FASD). Although FASD is associated with lifelong intellectual disability, the mechanisms …

Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively …

Cardiac regenerative therapy has received attention as a potentially revolutionary approach for treating the damaged heart. The mouse model of myocardial infarction (MI) remains one of the most common tools for the evaluation of such new therapies. …

There is general consensus that spinal cord injuries (SCI) above T6 result in altered sympathetic control of the heart,which negatively influences cardiac structure and function. To by-pass disrupted circuitry and investigate cardiac responses under …

Introduction: Types 1 and 2 diabetes have different causative mechanisms. Hence, different extent of cardiovascular, cognitive and auditory functions could be expected. Materials and methods: Body weight, blood glucose were measured in Wild type(WT), …