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Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease
Pancreatic ductal adenocarcinoma (PDA) has a highly immunosuppressive microenvironment, which is contributed by the complex interaction between cancer cells and a heterogeneous population of stromal cells. Therefore, facile and trackable models are needed …
Publication
Dysbiotic 1‐carbon metabolism in cardiac muscle remodeling
Unless there is a genetic defect/mutation/deletion in a gene, the causation of a given disease is chronic dysregulation of gut metabolism. Most of the time, if not always, starts within the gut; that is what we eat. Recent research shows that the …
Publication
Contribution of DNA methylation in chronic stress‐induced cardiac remodeling and arrhythmias in mice
It is recognized that stress can induce cardiac dysfunction, but the underlying mechanisms are not well understood. The present study aimed to test the hypothesis that chronic negative stress leads to alterations in DNA methylation of certain cardiac …
Publication
Spectral Signatures in the Different Layers of the Human Eyelid by Photoacoustic Imaging
Background and Objectives: The eyelids are susceptible to a number of skin cancers, which are challenging to excise radically without sacrificing excessive healthy tissue. Photoacoustic (PA) imaging is an emerging non-invasive biomedical imaging modality …
Publication
Pioglitazone downregulates Twist-1 expression in the kidney and protects renal function of Zucker diabetic fatty rats
Aims: Renal interstitial fibrosis and glomerulosclerosis are the characteristic presentation of diabetic nephropathy progression. Twist-1 overexpression contributes to renal fibrosis. Previous studies have demonstrated that pioglitazone (PIO), a PPAR-γ …
Publication
Crystal structure, molecular docking and protective activity on myocarditis of Co(II) coordination polymer based nanoparticles
This work presents the synthesis and characterization of a dicyanamide-bridged coordination polymer [Co(L)2(dca)]n (1) by using the bidentate NO donor Schiff base ligand (2-methoxy-6-((methylimino)methyl)phenol. Furthermore, the nanoparticles of complex 1 …
Publication
Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer resistant to immunotherapy. We create a PDAmouse model and show that neoantigen expres- sion is required for intratumoral T cell accumulation and response to immune checkpoint blockade. By …
Publication
Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress
The intermediate filament (IF) cytoskeleton has been proposed to regulate morphogenic processes by integrating the cell fate signaling machinery with mechanical cues. Signaling between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) …
Publication
Bilayered Polymeric Micro- and Nanofiber Vascular Grafts as Abdominal Aorta Replacements: Long-Term in Vivo Studies in a Rat Model
In vivo long-term evaluation of degradable implants offers valuable information for the further design and optimization of biomaterials. In this study, we prepared one type of bilayer graft, which had an internal layer of oriented elastic degradable …
Publication
TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically, the identification of negative regulators of cardiomyocyte protein synthesis is needed. Here, …