Objective . Sentinel node biopsy in patients with cutaneous melanoma improves staging, provides prognostic information, and leads to an increased survival in node-positive patients. However, frozen section analysis of the sentinel node is not reliable and …

Photoacoustic imaging combines the high contrast of optical imaging with the spatial resolution and penetration depth of ultrasound. This technique holds tremendous potential for imaging in small animals and importantly, is clinically translatable. At …

Preclinical, noninvasive imaging of tissue engineering polymeric scaffold structure and/or the physiological processes such as blood oxygenation remains a challenge. In vitro or ex vivo, the widely used scaffold characterization modalities such as …

Metastases rather than primary tumors are responsible for killing most patients with cancer. Cancer cells often invade regional lymph nodes (LN) before colonizing other parts of the body. However, due to the low sensitivity and specificity of current …

Live ultrasound (left) and photoacoustic (right) coronal section of a mouse brain during ligation of the right common carotid artery. The red, white and blue color represents a parametric map of oxygen saturation clearly showing the drop in sO 2 in the …

We have previously demonstrated that adult transgenic C57BL/6J mice with CM-restricted overexpression of the dominant negative Wv mutant protein (dn-c-kit-Tg) respond to pressure overload with robust cardiomyocyte (CM) cell cycle entry. Here, we tested if …

Recent smooth muscle cell (SMC) lineage tracing studies have revealed SMCs undergo remarkable changes in phenotype during development of atherosclerosis. Of major interest, we demonstrated that KLF4 in SMC is detrimental for overall lesion pathogenesis in …

Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis. In this study, we prepared multifunctional microspheres from …

Sodium bicarbonate (NaHCO3) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet the mechanisms mediating this effect remain unclear. The Dahl salt-sensitive (SS) rat develops hypertension and progressive renal injury …