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Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish
Deterioration or inborn malformations of the cardiac conduction system (CCS) interfere with proper impulse propagation in the heart and may lead to sudden cardiac death or heart failure. Patients afflicted with arrhythmia depend on antiarrhythmic …
Publication
Resolvin D4 attenuates the severity of pathological thrombosis in mice
Deep vein thrombosis (DVT) is a common cardiovascular disease with a major effect on quality of life, and safe and effective therapeutic measures to efficiently reduce existent thrombus burden are scarce. Using a comprehensive targeted liquid …
Publication
Inhibition of the LncRNA Gpr19 attenuates ischemia‐reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR‐324‐5p/Mtfr1 axis
Reperfusion therapy after acute myocardial infarction (AMI) can effectively restore the blood supply and nutritional support of ischemic myocardium and save the dying myocardium. However, myocardial ischaemia-reperfusion (I/R) injury has become a new …
Publication
Genome-wide differential expression profiling of lncRNAs and mRNAs associated with early diabetic cardiomyopathy
Diabetic cardiomyopathy is one of the main causes of heart failure and death in patients with diabetes. There are no effective approaches to preventing its development in the clinic. Long noncoding RNAs (lncRNA) are increasingly recognized as important …
Publication
A bivalent antihypertensive vaccine targeting L‐type calcium channels and angiotensin AT 1 receptors
Background and Purpose: Hypertension has been the leading preventable cause of premature death worldwide. The aim of this study was to design a more efficient vac- cine against novel targets for the treatment of hypertension. Experimental Approach: The …
Publication
Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis
Pyroptosis is a form of inflammatory cell death that could be driven by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation following myocardial infarction (MI). Emerging evidence …
Publication
Self-Assembled Polysaccharide–Diphenylalanine/Au Nanospheres for Photothermal Therapy and Photoacoustic Imaging
Gold-based nanomaterials have attracted extensive interest for potential application in photothermal therapy (PTT) owing to their distinctive properties including high photothermal transduction, biocompatibility, and low cytotoxicity. Herein, assembled …
Publication
Effects of hyperoxia on alveolar and pulmonary vascular development in germ-free mice
Airway microbial dysbiosis is associated with subsequent bronchopulmonary dysplasia (BPD) development in very preterm infants. However, the relationship of airway microbiome in normal pulmonary development has not been defined. To better understand the …
Publication
p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin
Despite the high and preferential expression of p38gMAPK in themyocardium, little is known about its function in the heart. The aimof the current studywas to elucidate the physiologic and biochemical roles of p38g in the heart. Expression and subcellular …
Publication
The Long Non‐coding RNA NR_045363 Regulates Cardiomyocyte Apoptosis and Cardiac Repair Through Activating P53 Signal Pathway
Long noncoding RNAs (lncRNAs) can participate in various biological behaviors, including regulating cell differentiation, proliferation and apoptosis. The investigators have previously confirmed that highly conserved lncRNA NR_045363 controls …