Recently, perfluorocarbon (PFC) nanodroplets were introduced as contrast agents for imaging and image-guided therapy. For example, in sonography, high-intensity ultrasound pulses were used to phase-transition liquid perfluorocarbon to produce gas …

Multimodal imaging-guided photothermal therapy (PTT), for the therapy of cancer, based on a ferritin (FRT) nanocage loaded with the near-infrared dye IR820 (designated DFRT) is demonstrated. The dual roles of DFRT (in imaging and PTT) are successfully …

The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research …

Head and neck cancer is the fifth most common type of cancer worldwide and remains challenging for effective treatment due to the proximity to critical anatomical structures in the head and neck region, which increases the probability of toxicity from …

Doxorubicin-loaded hollow nanoshells (Dox@PEG-HAuNS) increases the efficacy of photothermal ablation (PTA) by not only mediating efficient PTA but also through chemotherapy, and therefore have potential utility for local anticancer therapy. However, in …

Ultrasound offers signifi cant potential as a molecular imaging modality when imaging microbubble agents owing to single-bubble sensitivity. However, these agents are typically too large to escape the vascular system. Photoacoustic imaging is a novel …

Photoacoustic imaging, frequently coregistered with ultrasonic imaging, can provide functional and cellular/ molecular information about tissue within the anatomical land- marks of an imaged region. This review details the fundamen- tals of photoacoustic …

Alterations in tumor perfusion and microenvironment have been shown to be associated with aggressive cancer phenotypes, raising the need for noninvasive methods of tracking these changes. Dynamic contrast enhanced ultrasound (DCEUS) and photoacoustic (PA) …

Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed …

Summary: Photoacoustic imaging imparts the ability to distinguish materials according to their differences in optical absorp- tion (ie, their color) with the high spatial and temporal resolution of ultrasonography (US). Experiments in rats show the …