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A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post myocardial infarction
Aims: Myelomonocytic cells are critical in injury and healing post myocardial infarction (MI). Mechanisms of regulation, however, are incompletely understood. The aim of the study was to elucidate the role of interferon gamma (IFN-γ) in the orchestrated …
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Development of a quantitative method for evaluating small intestinal motility using ultrasonography in mice
Upper gastrointestinal (GI) motility is affected by various drugs and diseases. However, changes in upper GI motility during these conditions are not well understood, as there are few quantitative in vivo methods that assess small intestinal motility in …
Publication
A Novel Traditional Chinese Medicine ameliorates fatigue-induced cardiac hypertrophy and dysfunction via regulation of energy metabolism
Aims：Prolonged exercise and exercise training can adversely affect cardiac function in some individuals. QiShenYiQi Pills® (QSYQ), a compound Chinese medicine，has been previously shown to improve pressure overload-induced cardiac hypertrophy. We …
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Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF- κ B/TNF- α Signaling Pathway
Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition. NF- κ B and TNF- α have been implicated in the activation of the aging process, but the signaling molecules responsible for the …
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ACE inhibitor suppresses cardiac remodeling after myocardial infarction by regulating dendritic cells and AT2 receptor-mediated mechanism in mice
Dendritic cells (DCs) play a complex role in the progression of myocardial infarction (MI). The impact of an- giotensin-converting enzyme (ACE) inhibitor therapy, partly via affecting DCs maturation and recruitment, was tested on a MI mouse model. …
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Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF
Five-year survival for pancreatic ductal adenocarcinoma (PDAC) patients remains below 7% due to the lack of effective treatments. Here, we report that combined ablation of EGFR and c-RAF expression results in complete regression of a significant …
Publication
Lipid Shell Composition Plays a Critical Role in the Stable Size Reduction of Perfluorocarbon Nanodroplets
—Perfluorocarbon nanodroplets (PFCnDs) are phase-change contrast agents that have the potential to enable extravascular contrast-enhanced ultrasound and photoacoustic (US/PA) imaging. Producing consistently small, monodisperse PFCnDs remains a challenge …
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Sacubitril/Valsartan Decreases Cardiac Fibrosis in Left Ventricle Pressure Overload by Restoring PKG Signaling in Cardiac Fibroblasts
BACKGROUND: Heart failure (HF) is invariably accompanied by development of cardiac fibrosis, a form of scarring that increases muscular tissue rigidity and decreases cardiac contractility. Cardiac fibrosis arises from a pathological attempt to repair …
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Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice
Transverse aortic constriction (TAC) is a well-established model of pressure overload-induced cardiac hypertrophy and failure in mice. The degree of constriction “tightness” dictates the TAC severity and is determined by the gauge (G) of needle used. …
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The mechanical role of a cytoskeletal protein, Synemin, in bone, heart and skeletal muscle
Intermediate filaments (IFs) represent a major cytoskeletal network contributing to force transmission, cell shape and structure, adhesion and motility, subcellular scaffolding and tissue resilience, thereby modulating a range of cellular activities. …