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Probing the Cellular Size Distribution in Cell Samples Undergoing Cell Death
A polydisperse scattering model adapted for concentrated medium, namely the polydisperse structure factor model, was examined to explain the backscatter coefficients (BSCs) measured from packed cell samples undergoing cell death. Cell samples were scanned …
Publication
Quantitative Ultrasound in Ex Vivo Fibrotic Rabbit Livers
Liver fibrosis is the common result of chronic liver disease. Diagnosis and grading liver fibrosis for patient management is mainly based on blood tests and hepatic puncture-biopsy, which is particularly invasive. Quantitative ultrasound (QUS) techniques …
Publication
Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice
Stress is increasingly associated with heart dysfunction and is linked to higher mortality rates in patients with cardiometabolic disease. Glucocorticoids are primary stress hormones that regulate homeostasis through two nuclear receptors, the …
Publication
On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics
On-Demand Detaching Nanosystem for the Spatiotemporal Control of Cancer Theranostics …
Publication
Intraoperative evaluation of cervical nerve root avulsion using ultra–high-frequency ultrasound system
Avulsion of C5 and C7 nerve roots was confirmed intraoperatively in a 21 year old male present- ing after motor vehicle accident with confirmed absence of somatosensory evoked potentials upon stimulation via ultra–high-frequency ultrasound (70MHz). …
Publication
A viscoelastic adhesive epicardial patch for treating myocardial infarction
Acellular epicardial patches that treat myocardial infarction by increasing the mechanical integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy. Here, we introduce a viscoelastic adhesive patch, made of an ionically …
Publication
The role of fibroblast – Cardiomyocyte interaction for atrial dysfunction in HFpEF and hypertensive heart disease
Aims: Atrial contractile dysfunction is associated with increased mortality in heart failure (HF). We have shown previously that a metabolic syndrome-based model of HFpEF and a model of hypertensive heart disease (HHD) have impaired left atrial (LA) …
Publication
Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo
Most solid tumors are characterized by highly dense, isotropic vessel networks. Characterization of such features has shown promise for early cancer diagnosis. Ultrasound diffusion has been used to characterize the micro-architecture of complex media, …
Publication
Characterization and Imaging of Lipid-Shelled Microbubbles for Ultrasound-Triggered Release of Xenon
Xenon (Xe) is a bioactive gas capable of reducing and stabilizing neurologic injury in stroke. The goal of this work was to develop lipid-shelled microbubbles for xenon loading and ultrasound-triggered release. Microbubbles loaded with either xenon …
Publication
Systemic and cardiac susceptibility of immune compromised mice to doxorubicin
Background: Anthracycline chemotherapy is an effective and widely used treatment for solid tumors and hematological malignancies regardless of its known cardiotoxicity. The mechanisms of the cardiotoxicity are not fully understood and methods to protect …