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Publication
Skeletal muscle regeneration with robotic actuation–mediated clearance of neutrophils
Mechanical stimulation (mechanotherapy) can promote skeletal muscle repair, but a lack of reproducible protocols and mechanistic understanding of the relation between mechanical cues and tissue regeneration limit progress in this field. To address these …
Publication
A novel two-component, expandable bioadhesive for exposed defect coverage: Applicability to prenatal procedures
Background/purpose: We sought to test select properties of a novel, expandable bioadhesive composite that allows for enhanced adhesion control in liquid environments. Methods: Rabbit fetuses (n = 23) underwent surgical creation of spina bifida on …
Publication
Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior
Aging is the largest risk factor for Achilles tendon associated disorders and rupture. Although Achilles tendon macroscale elastic properties are suggested to decline with aging, less is known about the effect of maturity and aging on multiscale …
Publication
Degradable and Removable Tough Adhesive Hydrogels
The development of tough adhesive hydrogels has enabled unprecedented adhesion to wet and moving tissue surfaces throughout the body, but they are typically composed of nondegradable components. Here, a family of degradable tough adhesive hydrogels …
Publication
Controlled Delivery of Corticosteroids Using Tunable Tough Adhesives
Hydrogel-based drug delivery systems typically aim to release drugs locally to tissue in an extended manner. Tissue adhesive alginate-polyacrylamide tough hydrogels are recently demonstrated to serve as an extended-release system for the corticosteroid …
Publication
Super-Resolution Ultrasound Localization Microscopy using High-Frequency Ultrasound to Measure Ocular Perfusion Velocity in the Rat Eye
Imaging of the ocular vasculature can provide new insights into the pathophysiology of 1 ocular diseases. This study proposes a novel high-frequency super-resolution ultrasound localization 2 microscopy (SRULM) technique and evaluates its ability to …
Publication
Recent advances in photoacoustic blind source spectral unmixing approaches and the enhanced detection of endogenous tissue chromophores
Recently, the development of learning-based algorithms has shown a crucial role to extract features of vital importance from multi-spectral photoacoustic imaging. In particular, advances in spectral photoacoustic unmixing algorithms can identify tissue …
Publication
Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling
Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling …
Publication
Hypoxia-Responsive Aggregation of Gold Nanoparticles for Near-Infrared-II Photoacoustic Imaging-Guided Enhanced Radiotherapy
By directly harming cancer cells, radiotherapy (RT) is a crucial therapeutic approach for the treatment of cancers. However, the efficacy of RT is reduced by the limited accumulation and short retention time of the radiosensitizer in the tumor. Herein, we …
Publication
Mesocrystalline ZnS nanoparticles-augmented sonocatalytic full water splitting into H2/O2 for immunoactivating deep tumor
Mesocrystalline ZnS nanoparticles-augmented sonocatalytic full water splitting into H2/O2 for immunoactivating deep tumor …