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Axitinib attenuates intraplaque angiogenesis, haemorrhages and plaque destabilization in mice
Aim: An increased density of intraplaque (IP) microvessels in ruptured versus nonruptured human plaques suggests that IP neovascularization has a major causative effect on plaque development and instability. Possibly, vascular endothelial growth factor …
Publication
Overexpression of microRNA-138 attenuates cardiac hypertrophic response through repression of YAP1
MicroRNAs (miRNAs) have been identified as important players in the pathogenesis of cardiac hypertrophy. In the present study, we evaluated the potential role of miR-138 in cardiac hypertrophy and the potential molecular mechanisms. We observed that in …
Publication
Photoacoustic imaging of lymphatic pumping
The lymphatic system is crucial for maintaining fluid balance in tissues and for immune cell trafficking; however, there are only a few methods for imaging lymphatic function in vivo. Lymph node biopsies are a common approach to diagnose illness; however, …
Publication
Detrimental role of lysyl oxidase in cardiac remodeling
A key feature of heart failure is adverse extracellular matrix (ECM) remodeling, which is associated with increases in the collagen cross-linking enzyme, lysyl oxidase (LOX). In this study, we assess the progression of cardiovascular remodeling from the …
Publication
A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model
This study was designed to investigate the effect of single-dose radiation therapy (RT) in combination with evofosfamide (TH-302), a hypoxia-activated prodrug, in a pre-clinical model of pancreatic cancer. AsPC1 tumors were implanted orthotopically in the …
Publication
Altered Penile Caveolin Expression in Diabetes: Potential Role in Erectile Dysfunction
Background The pathophysiology of increased severity of erectile dysfunction in men with diabetes and their poor response to oral pharmacotherapy are unclear. Defective vascular endothelium and consequent impairment in the formation and action of nitric …
Publication
The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy
Recently, linkage analysis of two large unrelated multigenerational families identified a novel dilated cardiomyopathy (DCM)-linked mutation in the gene coding for alpha-tropomyosin (TPM1) resulting in the substitution of an aspartic acid for an …
Publication
CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα 12/13
The arachidonic acid-cytochrome P450 2J2-ep- oxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular sys- tem. This study explored the effects of the AA-CYP2J2-EET metabolic pathway on cardiac …
Publication
Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth
BACKGROUND Exercise promotes metabolic remodeling in the heart, which is associated with physiological cardiac growth; however, it is not known whether or how physical activity-induced changes in cardiac metabolism cause myocardial remodeling. In this …
Publication
Dysfunction of Myosin light-chain 4 (MYL4) leads to heritable atrial cardiomyopathy with electrical, contractile, and structural components: Evidence from genetically-engineered rats
© 2017 The Authors. Background--There is increasing interest in the concept of atrial cardiomyopathy, but the underlying molecular and mechanistic determinants remain poorly defined. We identified a family with heritable atrial cardiomyopathy manifesting …