Search
Publication
Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice
Cell-based cardiac therapy is a promising therapeutic strategy to restore heart function after myocardial infarction (MI). However, the cell type selection and ensuing effects remain controversial. Here, we intramyocardially injected Isl1+ cardiac …
Publication
Multiphasic Regulation of Systemic and Peripheral Organ Metabolic Responses to Cardiac HypertrophyCLINICAL PERSPECTIVE
Background—Reduced fat oxidation in hypertrophied hearts coincides with a shift of carnitine palmitoyl transferase I from muscle to increased liver isoforms. Acutely increased carnitine palmitoyl transferase I in normal rodent hearts has been shown to …
Publication
Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood PressureClinical Perspective
Background. Hypertension due to increased renin angiotensin system (RAS) activation is associated with elevated reactive oxygen species (ROS) production. Previous studies implicate NADPH oxidase (Nox) proteins as important ROS sources during RAS …
Publication
Left ventricular remodeling leads to heart failure in mice with cardiac‐specific overexpression of VEGF‐B 167 : echocardiography and magnetic resonance imaging study
Cardiac-specific overexpression of vascular endothelial growth factor (VEGF)- B167 is known to induce left ventricular hypertrophy due to altered lipid meta- bolism, in which ceramides accumulate to the heart and cause mitochondrial damage. The aim of …
Publication
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca 2+ –Dependent Antioxidant Response
Diabetic cardiomyopathy is a major cause of mortality in diabetic patients, but specific strategies for prevention or treatment of diabetic cardiomyopathy have not been clarified yet. MICU1 is a key regulator of mitochondria Ca(2+) uptake, which plays …
Publication
Effects of Total Flavone from Rhododendron simsii Planch. Flower on Postischemic Cardiac Dysfunction and Cardiac Remodeling in Rats
This study investigated the effect of total flavone from Rhododendron simsii Planch. flower (TFR) on postischemic cardiac dysfunction and ventricular remodeling and was to test the hypothesis that TFR has an antiventricular remodeling effect through …
Publication
SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction
SIRT1 has been proved to rejuvenate and improve the therapeutic efficacy of aged rat mesenchymal stem cells (MSCs). Herein, we investigate the protective effect of pretreatment with SIRT1 activator SRT1720 on aged human MSCs (hMSCs). The optimized …
Publication
Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation
Maternal nicotine exposure causes alteration of gene expression and cardiovascular programming. The discovery of nicotine-medicated regulation in cardiogenesis is of major importance for the study of cardiac defects. The present study investigated the …
Publication
T cell costimulation blockade blunts pressure overload-induced heart failure
Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. Searching for better …
Publication
Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, …