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Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries
Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial …
Publication
Effect and functional mechanism of induced pluripotent stem cells on myocardial fibrosis after cardiac infarction
Acute myocardial infarction (AMI) has a high incidence and causes severe consequences. Induced plu- ripotent stem (iPS) cells derives from patient’s own cells and has become one research focus for treating cardiovas- cular disease. The role and function …
Publication
Doxycycline protects against ROS-induced mitochondrial fragmentation and ISO-induced heart failure
In addition to their anti-bacterial action, tetracyclines also have complex biological effects, including the modification of mitochondrial protein synthesis, metabolism and gene-expression. Long-term clinical studies have been performed using …
Publication
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O2-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth …
Publication
Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction
Left ventricular (LV) remodeling following a myocardial infarction (MI) involves formation of reactive oxygen species (ROS). Paroxetine, a selective serotonin reuptake inhibitor, has an antioxidant effect in the vascular wall. We investigated whether …
Publication
Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
Salusin-β accelerates inflammatory responses in vascular endothelial cells, and increases oxidative stress in vascular smooth muscle cells. Plasma salusin-β levels were increased in diabetic patients. This study was designed to determine whether salusin-β …
Publication
Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase-induced cardiomyopathy: involvement of mitofusin-2
Background and purpose The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived …
Publication
Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure
Qishenkeli (QSKL) is one of the Chinese medicine formulae for treating heart failure and has been shown to have an antifibrotic effect. However, the mechanism of its therapeutic effects remains unclear. In this study, we aimed to explore whether QSKL …
Publication
TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages
Background We have recently shown that the expression of the transient receptor potential vanilloid 2 channel, TRPV2, is upregulated in the peri-infarct zone 3–5 days following an acute myocardial infarction (AMI). Further analysis has demonstrated that …
Publication
Isolation of human explant derived cardiac stem cells from cryopreserved heart tissue
The value of preserving high quality bio specimens for fundamental research is significant as linking cellular and molecular changes to clinical and epidemiological data has fueled many recent advances in medicine. Unfortunately, storage of traditional …