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Simultaneous vascular strain and blood vector velocity imaging using high frequency versus conventional frequency plane wave ultrasound: a phantom study
Plaque strain and blood vector velocity imaging of stenosed arteries are expected to aid in diagnosis and prevention of cerebrovascular disease. Ultrafast plane wave imaging enables simultaneous strain and velocity estimation. Multiple ultrasound vendors …
Publication
In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18 F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
Reactive oxygen species (ROS) are involved in doxorubicin-induced cardiotoxicity. The authors investigated the efficacy of18F-DHMT, a marker of ROS, for early detection of doxorubicin-induced cardiotoxicity in rats. Echocardiography was performed at …
Publication
Intravesical Activation of the Cation Channel TRPV4 Improves Bladder Function in a Rat Model for Detrusor Underactivity
Background: Improvement of bladder emptying by modulating afferent nerve activity is an attractive therapeutic strategy for detrusor underactivity. Transient receptor potential vanilloid 4 (TRPV4) is a sensory ion channel in urothelial cells that …
Publication
The 13C hyperpolarized pyruvate generated by ParaHydrogen detects the response of the heart to altered metabolism in real time
Many imaging methods have been proposed to act as surrogate markers of organ damage, yet for many candidates the essential biomarkers characteristics of the injured organ have not yet been described. Hyperpolarized [1-13C]pyruvate allows real time …
Publication
Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice
The aim of this research is to investigate the therapeutic effect of GGQL decoction on cardiac dysfunction and elucidate the pharmacological mechanisms. db/db mice were divided into DB group or GGQL group, and WT mice were used as control. All mice were …
Publication
Mouse Oocytes Acquire Mechanisms That Permit Independent Cell Volume Regulation at the End of Oogenesis
Normal pregnancy is associated with decreased uterine vascular contraction and increased blood flow even though angiotensin II (AngII) levels are increased. AngII not only activates the angiotensin type 1 receptor (AT1R) to mediate vasoconstriction but …
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Mapping macrophage polarization over the myocardial infarction time continuum.
In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and scar formation. We hypothesized that macrophages undergo polarization state changes over the MI time course and assessed macrophage polarization transcriptomic …
Publication
Pathophysiological mapping of experimental heart failure: Left and right ventricular remodeling in transverse aortic constriction is temporally, kinetically and structurally distinct
© 2018 Platt, Huber, Romanova, Brunt and Simpson. A growing proportion of heart failure (HF) patients present with impairments in both ventricles. Experimental pressure-overload (i.e., transverse aortic constriction, TAC) induces left ventricle (LV) …
Publication
Honokiol protects against anti-β1-Adrenergic Receptor Autoantibodies-induced myocardial dysfunction via activation of autophagy
Myocardial diseases are prevalent syndromes with high mortality rate. The exploration of effective interference is important. Anti-β1- Adrenergic Receptor Autoantibodies (β1-AAB) is highly correlated with myocardial dysfunction. The actions and underlying …
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Multimode ultrasound viscoelastography for three-dimensional interrogation of microscale mechanical properties in heterogeneous biomaterials
Both static and time-dependent mechanical factors can have a profound impact on cell and tissue function, but it is challenging to measure the mechanical properties of soft materials at the scale which cells sense. Multimode ultrasound viscoelastography …