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An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease
Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation causes cardiac lesions remains elusive. Here we report the involvement of Wnt/β-catenin signaling in this process. In rats with …
Publication
Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis
Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis …
Publication
Bio-ink properties and printability for extrusion printing living cells
Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclero- tic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a …
Publication
Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers
Increasing occurrences of degenerative diseases, defective tissues, and severe cancers heighten the importance of advanced biomedical treat- ments, which in turn enhance the need for improved biomaterials with versatile theranostic functionalities yet …
Publication
A Novel Fibroblast Activation Inhibitor Attenuates Left Ventricular Remodeling and Preserves Cardiac Function in Heart Failure
BACKGROUND: Cardiac fibroblasts are critical mediators of fibrotic remodeling in the failing heart and transform into myofibroblasts in the presence of pro-fibrotic factors such as TGF-β. Myocardial fibrosis worsens cardiac function accelerating the …
Publication
Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis
Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, the biological role of …
Publication
Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anemia
Exposure to high altitude worsens symptoms and crises in patients with sickle cell disease (SCD). However, it remains unclear if prolonged exposure to low barometric pressures exacerbates SCD etiologies or impairs quality of life. We tested the hypothesis …
Publication
Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
Cardiomyocyte proliferation stops at birth when the heart is no longer exposed to maternal blood and, likewise, to regulatory T cells (Tregs) that are expanded to promote maternal tolerance towards the fetus. Here, we report a role of Tregs in promoting …
Publication
Hedgehog Signaling in Neonatal and Adult Lung
Rationale: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular …
Publication
Atglistatin Ameliorates Functional Decline in Heart Failure via Adipocyte-specific Inhibition of Adipose Triglyceride Lipase
Rationale: Despite the advancement in therapies for cardiovascular disease and heart failure (HF), the incidence and prevalence of HF is increasing. Previous work has suggested that inhibiting adipose triglyceride lipase (ATGL) in adipose tissue during HF …