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Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats
BACKGROUND Heart failure is associated with altered gene expression and DNA methylation. De novo DNA methylation is associated with gene silencing, but its role in cardiac pathology remains incompletely understood. We hypothesized that inhibition of DNA …
Publication
High birth weight was associated with increased radial artery intima thickness but not with other investigated cardiovascular risk factors in adulthood
Aim This study investigated whether a high birth weight was associated with increased risk factors for cardiovascular disease when Swedish adults reached 34-40. Methods We studied 27 subjects born at Uppsala University Hospital in 1975-1979, weighing at …
Publication
Treatment of SEC62 over-expressing tumors by Thapsigargin and Trifluoperazine
Treatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to this treatment. …
Publication
Extracellular signal-regulated kinase (ERK) activation preserves cardiac function in pressure overload induced hypertrophy
Background: Chronic pressure overload and a variety ofmediators induce concentric cardiac hypertrophy.When prolonged, cardiac hypertrophy culminates in decreasedmyocardial function and heart failure. Activation of the extracellular signal-regulated kinase …
Publication
Long-term safety and efficacy of AAV gene therapy in the canine model of glycogen storage disease type Ia
Background Viral mediated gene therapy has progressed after overcoming early failures, and gene therapy has now been approved for several conditions in Europe and the USA. Glycogen storage disease (GSD) type Ia, caused by a deficiency of …
Publication
PCSK9 expression in the ischemic heart and its relationship to infarct size, cardiac function and development of autophagy
Background: Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel therapy to treat hypercholesterolemia and related cardiovascular diseases. This study determined if PCSK9 can regulate infarct size, cardiac function …
Publication
Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61α in mouse hearts
Cardiac fibrosis is an independent risk factor for heart failure and even the leading cause of death in myocardial infarction patients. However, molecular mechanisms associated with the pathogenesis of cardiac fibrosis following myocardial infarction are …
Publication
Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis
Aims Sepsis-caused multiple organ failure remains the major cause of morbidity and mortality in intensive care units. Nicotinamide riboside (NR) is a precursor of nicotinamide adenine dinucleotide (NAD+), which is important in regulating oxidative stress. …
Publication
Perivascular Adipose Tissue-Derived PDGF-D Contributes to Aortic Aneurysm Formation during Obesity
Obesity increases the risk of vascular diseases, including aortic aneurysm (AA). Perivascular adipose tissue (PVAT) surrounding arteries are altered during obesity. However, the underlying mechanism of adipose tissue, especially PVAT, in the pathogenesis …
Publication
Performances of a Pristine Graphene-Microbubble Hybrid Construct as Dual Imaging Contrast Agent and Assessment of Its Biodistribution by Photoacoustic Imaging
Coupling near-infrared (NIR) nanoscale absorbing materials with microbubbles (MBs) can generate a multifunctional dual imaging contrast agent. A new approach is presented for a hybrid photoacoustic/ultrasound contrast enhancer where pristine graphene is …