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Data processing of 3D and 4D in-vivo electron paramagnetic resonance imaging co-registered with ultrasound. 3D printing as a registration tool
We present the concept of image registration using ultrasound (US) and electron paramagnetic resonance (EPR) imaging and discuss the benefits of this solution, as well as its limitations. Both phantoms and murine tumors were used to test US and EPR image …
Publication
Ambient fine particulate matter exposure induces cardiac functional injury and metabolite alterations in middle-aged female mice
Plenty of epidemiological studies have shown that exposure to ambient particulate matter (PM2.5)is linked to cardiovascular diseases (CVDs) in older even in middle-aged populations; however, experi- mental evidence through intuitive metabolic analysis to …
Publication
Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase
Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. Objective Our goal was to investigate the mechanisms of endothelial Nox4 in regulating …
Publication
Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model
Aortic stenosis (AS) is a degenerative heart condition characterized by fibrosis and narrowing of aortic valves (AV), resulting in high wall shear stress (WSS) across valves. AS is associated with high plasma levels of transforming growth factor-b1 …
Publication
Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes. A multitude of factors are involved in the pathogenesis of DCM including chronic inflammation and oxidative stress. We have recently shown that compound LF10 prevents …
Publication
Hydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes Induced by Intermittent Hypoxia in Rats
Obstructive sleep apnea (OSA) can cause intermittent changes in blood oxygen saturation, resulting in the generation of many reactive oxygen species (ROS). To discover new antioxidants and clarify the endoplasmic reticulum (ER) stress involved in cardiac …
Publication
Allogenic tissue-specific decellularized scaffolds promote long-term muscle innervation and functional recovery in a surgical diaphragmatic hernia model
Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle does not develop properly, thereby raising abdominal organs into the thoracic cavity and impeding lung development and function. Large diaphragmatic defects require …
Publication
Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing
AIMS The role of uncoupling protein 2 (UCP2) in cardiac adaptation to pressure overload remains unclear. In a classical model of left ventricular pressure overload genetic deletion of UCP2 (UCP2-/-) protected against cardiac hypertrophy and failure. …
Publication
Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy
Heart failure (HF) is the single largest cause for increased hospitalization after fine particulate matter (PM2.5) exposure. Patients with left HF often progress to right ventricular (RV) failure even with optimal medical care. An increase of PM2.5 of 10 …
Publication
Strain mapping from 4D ultrasound reveals complex remodeling in dissecting murine abdominal aortic aneurysms.
Current in vivo abdominal aortic aneurysm imaging approaches tend to focus on maximum diameter but do not measure 3D vascular deformation or strain. Complex vessel geometries, heterogeneous wall compositions, and surrounding structures can all influence …