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Biofabrication of a vascularized islet organ for type 1 diabetes
Islet transplantation is superior to extrinsic insulin supplementation in the treating severe Type 1 diabetes. However, its efficiency and longevity are limited by substantial islet loss post-transplantation due to lack of engraftment and vascular supply. …
Publication
Validation studies of a fluorescent method to measure placental glucose transport in mice
Introduction: Proper placental function is essential for optimal fetal growth in utero. Placental transfer of nutrients to the fetus can be measured using radiolabelled tracers, but non-radioactive methods have potential advantages. This study aimed to …
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Micro-ultrasound for preclinical imaging
Over the past decade, non-invasive preclinical imaging has emerged as an important tool to facilitate biomedical discovery. Not only have the markets for these tools accelerated, but the numbers of peer-reviewed papers in which imaging end points and …
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Spectral photoacoustic imaging to estimate in vivo placental oxygenation during preeclampsia
Preeclampsia is a pregnancy-related hypertensive disorder accounting for 14% of global maternal deaths annually. Preeclampsia — maternal hypertension and proteinuria — is promoted by placental ischemia resulting from reduced uteroplacental perfusion. …
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Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations
Based on their lobule location, hepatocytes display differential gene expression, including pericentral hepatocytes that surround the central vein, which are marked by Wnt-b-catenin signaling. Activating b-catenin mutations occur in a variety of liver …
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Myocardial-specific ablation of Jumonji and AT-rich interaction domain–containing 2 ( Jarid2 ) leads to dilated cardiomyopathy in mice
Cardiomyopathy is a common myocardial disease that can lead to sudden death. However, molecular mechanisms underlying cardiomyopathy remains unclear. Jarid2 is necessary for embryonic heart development, but functions of Jarid2 after birth remains to be …
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DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations
Rationale: Mutations in the LMNA gene, encoding lamin A/C (LMNA), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in laminopathies. Objective: To gain insights into the molecular pathogenesis of …
Publication
Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia
Background. Optimal phosphate control is an unmet need in chronic kidney disease (CKD). High serumphosphate increases calcification burden and is associatedwithmortality and cardio- vascular disease inCKD.Nicotinamide (NA) alone or in combi- nation with …
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We are IntechOpen , the world ' s leading publisher of Open Access books Built by scientists , for scientists TOP 1 % Control of a Proportional Hydraulic System
Goats have always been considered very useful animals. Goats success is related to its excellent adaptability to the diicult mountain conditions, extreme weather and low value feed acceptance, versatile habits and high production considering their size. …
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A mouse model of heart failure exhibiting pulmonary edema and pleural effusion: Useful for testing new drugs
Introduction: Mouse models of chronic heart failure (HF) have been widely used in HF research. However, the current HF models most often use the C57BL/6 mouse strain and do not show the clinically relevant characteristics of pulmonary congestion. In this …