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Combined ethanol and lauromacrogol sclerotherapy for ovarian endometriotic cysts: a retrospective clinical and experimental study
Combined ethanol and lauromacrogol sclerotherapy for ovarian endometriotic cysts: a retrospective clinical and experimental study …
Publication
HDACs-targeting photosensitizer-based local-therapy augmenting photoimmunotherapy in bladder cancer
Immune checkpoint inhibitors (ICIs) represent a promising therapeutic strategy in bladder cancer (BCa), while limited response rates as monotherapy significantly restrict clinical application. To address this, we prepared QTANHOH, a quinoxalinone-based …
Publication
Intratumoral therapeutic dust for chemo-photodynamic combination treatment
Implantable wireless ultrasound microdevices for intratumoral therapy are hindered by inadequate miniaturiza-tion for deep-seated sites and toxic lead-based piezoelectrics. Here, we report an injectable, lead-free, submillime-ter therapeutic dust …
Publication
Engineering Gold Nanoconstruct Architecture Dictates Absorption Efficiency and Photoacoustic Imaging Performance
Photoacoustic (PA) imaging combines the high contrast of optical modalities with the deep-tissue penetration and high-spatial resolution of ultrasound, making it an attractive technique for biomedical imaging. Gold nanoconstructs are among the most widely …
Publication
Cardiac Adaptation in a Murine Iliac Arteriovenous Fistula Model and the Impact of Sex and N-Acetylcysteine Supplementation
Hemodialysis arteriovenous fistulas(AVFs) promote left ventricular(LV) hypertrophy, a known predictor of cardiovascular mortality in patients with chronic kidney disease(CKD). AVF flow dynamics do not reliably predict cardiac remodeling suggesting …
Publication
The hidden impact of cage position on behavioral phenotyping and reproducibility
The hidden impact of cage position on behavioral phenotyping and reproducibility …
Publication
Nanocatalytic Immunotherapy Targeting Tumor-Resident Intracellular Bacteria for Triple-Negative Breast Cancer Treatment and Metastasis Suppression
Tumor-resident intracellular bacteria (TRIB) are prevalent within triple-negative breast cancer (TNBC). As integral components of the tumor pathological microenvironment, TRIB accelerate TNBC development by regulating cell proliferation, metabolism and …
Publication
High-Resolution Imaging via UHF-US–Based 3D Reconstruction in a 3D In Vivo Tumor Model
The chorioallantoic membrane (CAM) model resembles a preclinical in vivo platform for the engraftment of different tumors and is especially well-suited for the development and evaluation of novel cancer therapies. Due to the CAM′s extensive vascular …
Publication
Baricitinib Attenuates Dermal and Pulmonary Fibrosis in a Bleomycin-Induced Murine Scleroderma Model: A Longitudinal High-Frequency Ultrasonography Study
Background: The bleomycin (BLM)-induced murine model is the most widely used experimental model of systemic sclerosis, yet fibrosis is conventionally verified only at sacrifice. We asked whether high-frequency ultrasonography (HFUS) can track dermal …
Publication
Dual enzyme-powered nanomotors for cascade-amplified sonodynamic therapy of prostate cancer
The clinical application of sonodynamic therapy (SDT) remains limited by the intrinsic hypoxic tumor microenvironment and sonosensitizer accumulation, while starvation therapy suffers from enzymatic activity in vivo . To address these challenges, we …