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In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm
Aortic aneurysm is the most life-threatening complication in Marfan syndrome (MFS) patients. Doxycycline, a nonselective matrix metalloproteinases inhibitor, was reported to improve the contractile function and elastic fiber structure and organization in …
Publication
Graded murine wire-induced aortic valve stenosis model mimics human functional and morphological disease phenotype
Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treat- ments …
Publication
Combination of Ligusticum Chuanxiong and Radix Paeonia Promotes Angiogenesis in Ischemic Myocardium through Notch Signalling and Mobilization of Stem Cells
Objective . To study the cardioprotective mechanism by which the combination of Chuanxiong (CX) and Chishao (CS) promotes angiogenesis. Methods . Myocardial infarction (MI) mouse models were induced by ligation of the left anterior descending coronary …
Publication
FNDC5/Irisin inhibits pathological cardiac hypertrophy
Cardiac hypertrophy is a common pathophysiological process in various cardiovascular dis- eases, which still has no effective therapies. Irisin is a novel myokine mainly secreted by skeletal muscle and is believed to be involved in the regulation of …
Publication
YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo
Specialized adult somatic cells, such as cardiomyo- cytes (CMs), are highly differentiated with poor renewal capacity, an integral reason underlying or- gan failure in disease and aging. Among the least renewable cells in the human body, CMs renew …
Publication
(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease
BACKGROUND: The (pro)renin receptor [(P)RR)] is involved in the activation of local renin-angiotensin system and subsequent development of cardiovascular disease. We investigated the therapeutic effect of a (P)RR blocker, handle-region peptide (HRP), on …
Publication
Down-regulation of MYCN protein by CX-5461 leads to neuroblastoma tumor growth suppression
Purpose: MYCN oncogene amplification is an independent predictor of poor prognosis in neuroblastoma. CX-5461 is a small molecular inhibitor that prevents initiation of ribosomal RNA (rRNA) synthesis by RNA Pol I, down-regulating MYCN/MYC proteins. We …
Publication
Inorganic Arsenic Exposure Induces Sex Disparate Effects and Exacerbates Ischemia-Reperfusion Injury in the Female Heart
Arsenic is a common contaminant in drinking water throughout the world, and recent studies support a link between inorganic arsenic (iAS) exposure and ischemic heart disease in men and women. Female hearts exhibit an estrogen-dependent reduction in …
Publication
A near-infrared turn-on probe for in vivo chemoselective photoacoustic detection of fluoride ion
The detection of fluoride ion (F − ) in living subjects is of value for healthcare and environmental fields. Here, a near-infrared (NIR) turn-on photoacoustic (PA) probe composed of naphthalimide unit, namely LET-1, was developed for chemoselective …
Publication
Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease
Leigh syndrome is a mitochondrial disease characterized by neurological disorders, metabolic abnormality and premature death. There is no cure for Leigh syndrome; therefore, new therapeutic targets are urgently needed. In Ndufs4-KO mice, a mouse model of …