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Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions
Doxorubicin is among the essential medicines with a wide antitumor spectrum, but its clinical application is limited by its cardiotoxicity. We recently discovered that ROCK1 is a key molecule in mediating cardiac remodeling in response to various …
Publication
Effects of combined MCA and G-CSF treatment on myocardial fibrosis and apoptosis gene expression in rats with diastolic heart failure
Objective: To explore the therapeutic effect of combining meglumine cyclic adenosine (MCA) with granu- locyte colony-stimulating factor (G-CSF) in treating rats with diastolic heart failure (DHF). Methods: A total of 40 Sprague Dawley (SD) male rats were …
Publication
The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function
It is increasingly recognized that synthesis and turnover of cardiac triglyceride (TG) play a pivotal role in the regulation of lipid metabolism and function of the heart. The last step in TG synthesis is catalyzed by diacylglycerol:acyltransferase (DGAT) …
Publication
Cardiac-Specific Overexpression of Silent Information Regulator 1 Protects Against Heart and Kidney Deterioration in Cardiorenal Syndrome via Inhibition of Endoplasmic Reticulum Stress
BACKGROUND/AIMS Increased endoplasmic reticulum (ER) stress contributes to development of cardiorenal syndrome (CRS), and Silent Information Regulator 1 (SIRT1), a class III histone deacetylase, may have protective effects on heart and renal disease, by …
Publication
Fropofol decreases force development in cardiac muscle
Supranormal contractile properties are frequently associated with cardiac diseases. Anesthetic agents, including propofol, can depress myocardial contraction. We tested the hypothesis that fropofol, a propofol derivative, reduces force development in …
Publication
Apelin impairs myogenic response to induce diabetic nephropathy in mice
The cause of the invalid reaction of smooth muscle cells to mechanical stimulation that results in a dysfunctional myogenic response that mediates the disruption of renal blood flow (RBF) in patients with diabetes is debatable. The present study revealed …
Publication
In Vivo Evaluation of the Cardiovascular System of Mouse Embryo and Fetus Using High Frequency Ultrasound
Genetically engineered mice have been widely used for studying cardiovascular development, physiology and diseases. In the past decade, high frequency ultrasound imaging technology has been significantly advanced and applied to observe the cardiovascular …
Publication
Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart
Heart failure (HF) is characterized by reduced fatty acid (FA) utilization associated with mitochondrial dysfunction. Recent evidence has shown that enhancing FA utilization may provide cardioprotection against HF. Our aim was to investigate the effects …
Publication
In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR –/– ApoB 100/100 mice
Aims:Despite vast clinical experience linking diabetes and atherosclerosis, the molecular mechanisms leading to accelerated vascular damage are still unclear. Here, we investigated the effects of nuclear factor of activated T-cells inhibition on plaque …
Publication
Comprehensive renoprotective effects of ipragliflozin on early diabetic nephropathy in mice
Clinical and experimental studies have shown that sodium glucose co-transporter 2 inhibitors (SGLT2i) contribute to the prevention of diabetic kidney disease progression. In order to clarify its pharmacological effects on the molecular mechanisms …