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IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation
Inflammation resolution is important for scar formation following myocardial infarction (MI) and requires the coordinated actions of macrophages and fibroblasts. In this study, we hypothesized that exogenous interleukin-10 (IL-10), an anti-inflammatory …
Publication
Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy
The myocardial response to pressure overload involves coordination of multiple transcriptional, post- transcriptional, and metabolic cues. The previous studies show that one such metabolic cue, O-GlcNAc, is elevated in the pressure-overloaded heart, and …
Publication
ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation
Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study,\r\nwe focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards\r\nMI-induced cardiac fibrosis and try to reveal …
Publication
The PPAR pan-agonist bezafibrate ameliorates cardiomyopathy in a mouse model of Barth syndrome
BACKGROUND The PGC-1α/PPAR axis has been proposed as a potential therapeutic target for several metabolic disorders. The aim was to evaluate the efficacy of the pan-PPAR agonist, bezafibrate, in tafazzin knockdown mice (TazKD), a mouse model of Barth …
Publication
Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries
Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial …
Publication
Effect and functional mechanism of induced pluripotent stem cells on myocardial fibrosis after cardiac infarction
Acute myocardial infarction (AMI) has a high incidence and causes severe consequences. Induced plu- ripotent stem (iPS) cells derives from patient’s own cells and has become one research focus for treating cardiovas- cular disease. The role and function …
Publication
Doxycycline protects against ROS-induced mitochondrial fragmentation and ISO-induced heart failure
In addition to their anti-bacterial action, tetracyclines also have complex biological effects, including the modification of mitochondrial protein synthesis, metabolism and gene-expression. Long-term clinical studies have been performed using …
Publication
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O2-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth …
Publication
Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction
Left ventricular (LV) remodeling following a myocardial infarction (MI) involves formation of reactive oxygen species (ROS). Paroxetine, a selective serotonin reuptake inhibitor, has an antioxidant effect in the vascular wall. We investigated whether …
Publication
Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
Salusin-β accelerates inflammatory responses in vascular endothelial cells, and increases oxidative stress in vascular smooth muscle cells. Plasma salusin-β levels were increased in diabetic patients. This study was designed to determine whether salusin-β …