Search
Publication
Signalling mechanisms underlying doxorubicin and Nox2 NADPH oxidase-induced cardiomyopathy: involvement of mitofusin-2
Background and purpose The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived …
Publication
Effect of QSKL on MAPK and RhoA Pathways in a Rat Model of Heart Failure
Qishenkeli (QSKL) is one of the Chinese medicine formulae for treating heart failure and has been shown to have an antifibrotic effect. However, the mechanism of its therapeutic effects remains unclear. In this study, we aimed to explore whether QSKL …
Publication
TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages
Background We have recently shown that the expression of the transient receptor potential vanilloid 2 channel, TRPV2, is upregulated in the peri-infarct zone 3–5 days following an acute myocardial infarction (AMI). Further analysis has demonstrated that …
Publication
Isolation of human explant derived cardiac stem cells from cryopreserved heart tissue
The value of preserving high quality bio specimens for fundamental research is significant as linking cellular and molecular changes to clinical and epidemiological data has fueled many recent advances in medicine. Unfortunately, storage of traditional …
Publication
Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice
Cell-based cardiac therapy is a promising therapeutic strategy to restore heart function after myocardial infarction (MI). However, the cell type selection and ensuing effects remain controversial. Here, we intramyocardially injected Isl1+ cardiac …
Publication
Multiphasic Regulation of Systemic and Peripheral Organ Metabolic Responses to Cardiac HypertrophyCLINICAL PERSPECTIVE
Background—Reduced fat oxidation in hypertrophied hearts coincides with a shift of carnitine palmitoyl transferase I from muscle to increased liver isoforms. Acutely increased carnitine palmitoyl transferase I in normal rodent hearts has been shown to …
Publication
Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood PressureClinical Perspective
Background. Hypertension due to increased renin angiotensin system (RAS) activation is associated with elevated reactive oxygen species (ROS) production. Previous studies implicate NADPH oxidase (Nox) proteins as important ROS sources during RAS …
Publication
Left ventricular remodeling leads to heart failure in mice with cardiac‐specific overexpression of VEGF‐B 167 : echocardiography and magnetic resonance imaging study
Cardiac-specific overexpression of vascular endothelial growth factor (VEGF)- B167 is known to induce left ventricular hypertrophy due to altered lipid meta- bolism, in which ceramides accumulate to the heart and cause mitochondrial damage. The aim of …
Publication
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca 2+ –Dependent Antioxidant Response
Diabetic cardiomyopathy is a major cause of mortality in diabetic patients, but specific strategies for prevention or treatment of diabetic cardiomyopathy have not been clarified yet. MICU1 is a key regulator of mitochondria Ca(2+) uptake, which plays …
Publication
Effects of Total Flavone from Rhododendron simsii Planch. Flower on Postischemic Cardiac Dysfunction and Cardiac Remodeling in Rats
This study investigated the effect of total flavone from Rhododendron simsii Planch. flower (TFR) on postischemic cardiac dysfunction and ventricular remodeling and was to test the hypothesis that TFR has an antiventricular remodeling effect through …