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Removal of epicardial adipose tissue after myocardial infarction improves cardiac function
BACKGROUND: The aim of this study was to assess the role of lipolysis of epicardial adipose tissue (EAT) in cardiac function after myocardial infarction (MI). METHODS: We used a rat model of MI with or without EAT removal to study the effects of EAT …
Publication
Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism
To investigate whether metformin can improve the cardiac function through improving the mitochondrial function in model of heart failure after myocardial infarction. Male C57/BL6 mice aged about 8 weeks were selected and the anterior descending branch was …
Publication
Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress
Background and purpose: ST2 is one of the interleukin (IL)-1 receptor family members comprising of membrane-bound (ST2L) and soluble (sST2) isoforms. Clinical trials have revealed that serum sST2 levels predict outcome in patient with myocardial …
Publication
Biodegradable Polymeric Nanocapsules Prevent Cardiotoxicity of Anti-Trypanosomal Lychnopholide
Chagas disease is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi. New antitrypanosomal options are desirable to prevent complications, including a high rate of cardiomyopathy. Recently, a natural substance, lychnopholide, has …
Publication
A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure
Activated renin-angiotensin system (RAS) within the central nervous system has been implicated in sympathoexcitation during various disease conditions including congestive heart failure (CHF). In particular, activation of RAS in the paraventricular …
Publication
Cistanche deserticola ethanol extract attenuates left ventricular remodeling and dysfunction by reducing the inflammatory response after myocardial infarction
Objective: This study aimed to investigate whether Cistanche deserticola extract (CDE) exerted an inhibi- tory effect on the cardiac inflammatory response and prevented adverse remodeling after myocardial infarction (MI) in rats. Methods: Wistar rats were …
Publication
Echocardiographic Evaluation of Coronary Abnormalities and Cardiac Function in a Murine Model of Kawasaki Disease Using High-frequency Ultrasound
Background: Murine model of coronary arterial inflammation has been widely accepted as an animal model of and used in Kawasaki disease (KD). This study sought to evaluate the developmental changes of coronary arteries and cardiac function in a murine …
Publication
Danshen injection prevents heart failure by attenuating post-infarct remodeling
Danshen Injection (DSI) is a traditional Chinese medicine extracted from Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge. Danshen is an ancient antipyretic traditional Chinese medicine which is mostly used to improve blood …
Publication
Cardioprotection and lifespan extension by the natural polyamine spermidine
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and …
Publication
A Novel Murine Model of Marfan Syndrome Accelerates Aortopathy and Cardiomyopathy
Background. Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. Although significant advances in the understanding of …