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Predicting abdominal aortic aneurysm growth using high-frequency ultrasound

This study by Adelsperger et al. uses Vevo ultrasound imaging to generate predictive models for the formation and growth of abdominal aortic aneurysms (AAA).

Article Summary:

  • Clinically, it is important to know at what point AAA require surgical intervention
  • Angiotensin II is a very common mouse model for the study of AAA, however development of aneurysms is inconsistent and variable
  • There is a need to distinguish effects of treatment versus normal variability in aneurysm growth in the mouse
  • Vessel diameter, flow, 3D geometry, assessment of branching vessels and circumferential strain were measured by Vevo ultrasound
  • Measurements by ultrasound were highly correlated with histological findings
  • Analysis of ultrasound measurements allowed for successful prediction of aneurysm growth trends over time
  • Final size and length of aneurysm was successfully predicted


Conclusion:

Comprehensive ultrasound data can help differentiate between normal variability in aneurysm growth between animals and the significant benefits of a treatment of interest.


1. Adelsperger AR, Phillips EH, Ibriga HS, Craig BA, Green LA, Murphy MP, et al. Development and growth trends in angiotensin II-induced murine dissecting abdominal aortic aneurysms. Physiol Rep. 2018;6(8):1–17.

 

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