Search
Publication
Bio-inspired self-assembled bacteriochlorin nanoparticles for superior visualization and photothermal ablation of tumors
Background: Although hyperthermia-based photothermal therapy (PTT) has achieved great success in the battle against malignant tumors, various commonly used photothermal sensitizers still suffer from non-selective tumor accumulation, limited photothermal …
Publication
Assessing Cardiac Functions of Zebrafish from Echocardiography Using Deep Learning
Zebrafish is a well-established model organism for cardiovascular disease studies in which one of the most popular tasks is to assess cardiac functions from the heart beating echo-videos. However, current techniques are often time-consuming and …
Publication
A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice
Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. …
Publication
Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung injury without impairing innate immunity
In acute lung injury, the lung endothelial barrier is compromised. Loss of endothelial barrier integrity occurs in association with decreased levels of the tight junction protein claudin-5. Restoration of their levels by gene transfection may improve the …
Publication
Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease rat
Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease …
Publication
PVP-coated ultrasmall Nd-doped Gd2O2S nanoparticles for multimodal imaging
Rare-earth (RE) based inorganic nanoparticles (NPs) are emerging nanoprobes, which have been widely explored. Single RENPs as a contrast agent for multimodal bioimaging possess the ability to combine optical, ultrasonic, magnetic and electronic properties …
Publication
Mechanisms of Small Intestine Involvement in Obesity-Induced Atherosclerosis
To investigate the role of the small intestine in obesity-induced atherosclerosis and its molecular mechanisms using bioinformatics analysis and experimental validation. In the GSE59054 data, small intestine tissue samples from 3 normal and 3 obese mice …
Publication
Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma
Purpose: The mortality in patients with MYCN-amplified high-risk neuroblastoma remains greater than 50% despite advances in multimodal therapy. Novel therapies are urgently needed that requires preclinical evaluation in appropriate mice models. …
Publication
A novel onco-cardiological mouse model of lung cancer-induced cardiac dysfunction and its application in identifying potential roles of tRNA-derived small RNAs
A novel onco-cardiological mouse model of lung cancer-induced cardiac dysfunction and its application in identifying potential roles of tRNA-derived small …
Publication
Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Pneumonia elicits the production of cytotoxic beta amyloid (Ab) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation of the amyloidogenic pathway that produces cytotoxic Ab is unknown. Here, we tested the …