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Publication
Azilsartan ameliorates ventricular hypertrophy in rats suffering from pressure overload-induced cardiac hypertrophy by activating the Keap1–Nrf2 signalling pathway
Objectives Investigate if azilsartan protects against myocardial hypertrophy by upregulating nu- clear factor erythroid 2-related factor 2 (Nrf2)-mediated pathways. Methods Abdominal aortic constriction (AAC)-induced cardiac hypertrophy in rats was …
Publication
Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model
Purpose: While there is concern about degenerative tissue effects of exposure to space radiation during deep-space missions, there are no pharmacological countermeasures against these adverse effects. γ-Tocotrienol (GT3) is a natural form of vitamin E …
Publication
Telmisartan ameliorates cardiac fibrosis and diastolic function in cardiorenal heart failure with preserved ejection fraction
Chronic kidney disease (CKD) is a major contributor to the development of heart failure with preserved ejection fraction (HFpEF), whereas the underlying mechanism of cardiorenal HFpEF is still elusive. The aim of this study was to investigate the role of …
Publication
Instability in nad+ metabolism leads to impaired cardiac mitochondrial function and communication
Poly(ADP-ribose) polymerase (PARP) enzymes initiate (mt)DNA repair mechanisms and use nicotinamide adenine dinucleotide (NAD+) as energy source. Prolonged PARP activity can drain cellular NAD+ reserves, leading to de-regulation of important molecular …
Publication
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury
Aims: N6-Methyladenosine (m6A), one of the important epigenitic modifications, is very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in various diseases. However, the role of m6A modification in heart regeneration after injury …
Publication
Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure
SUMOylation of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) has been shown to play a critical role in the abnormal Ca2+ cycle of heart failure. Ginsenoside Rg3 (Rg3), the main active constituent of Panax ginseng, exerts a wide range of …
Publication
An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair
Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme …
Publication
Abnormalities in lysine degradation are involved in early cardiomyocyte hypertrophy development in pressure-overloaded rats
Background: Cardiomyocyte metabolism changes before cardiac remodeling, but its role in early cardiac hypertrophy detection remains unclear. This study investigated early changes in plasma metabolomics in a pressure-overload cardiac hypertrophy model …
Publication
Deletion of AT1a (Angiotensin II Type 1a) Receptor or Inhibition of Angiotensinogen Synthesis Attenuates Thoracic Aortopathies in Fibrillin1C1041G/+Mice
Objective: A cardinal feature of Marfan syndrome is thoracic aortic aneurysm. The contribution of the renin-angiotensin system via AT1aR (Ang II [angiotensin II] receptor type 1a) to thoracic aortic aneurysm progression remains controversial because the …
Publication
MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca2 þ release in hypertrophic rat cardiomyocytes
Cardiac dysfunction in heart failure (HF) and diabetic cardiomyopathy (DCM) is associated with aberrant intracellular Ca2 þ handling and impaired mitochondrial function accompanied with reduced mitochondrial calcium concentration (mito-[Ca2 þ ]). …