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Doxorubicin induces wide-spread transcriptional changes in the myocardium of hearts distinguishing between mice with preserved and impaired cardiac function
Aims: Doxorubicin (DOX) is an important drug for the treatment of various tumor entities. However, the occurrence of heart failure limits its application. This study investigated differential gene expression profiles in the left and right ventricles of …
Publication
Downregulated developmental processes in the postnatal right ventricle under the influence of a volume overload
The molecular atlas of postnatal mouse ventricular development has been made available and cardiac regeneration is documented to be a downregulated process. The right ventricle (RV) differs from the left ventricle. How volume overload (VO), a common …
Publication
Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model
The goal of the present study was to evaluate the diagnostic value of a joint distractor in arthroscopy in small-breed dogs. Sixty stifle joints, which were collected from thirty cadavers, were used in this study. To simulate different injuries, no medial …
Publication
Knockdown of Salusin- β Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats
Salusin-β is a biologically active peptide with 20 amino acids that exerts several cardiovascular activity-regulating effects, such as regulating vascular endothelial function and the proliferation of vascular smooth muscle cells. However, the regulatory …
Publication
Early treatment with combination of SS31 and entresto effectively preserved the heart function in doxorubicin-induced dilated cardiomyopathic rat
Background: This study tested the hypothesis that early administration of SS31 and entresto (En) was superior to either one alone on preserving the heart function in setting of dilated cardiomyopathy (DCM) induced by doxorubicin (Dox) [accumulated dosage …
Publication
Hirsutella sinensis fungus improves cardiac function in mouse model of heart failure
Cordyceps sinensis, including Hirsutella sinensis, is a highly valuable traditional Chinese medicine and is used to treat patients with pulmonary heart disease in clinical practice. However, the underlying mechanisms of its effects remain unclear. In this …
Publication
Effects of Angiotensin Converting Enzyme 2 and Angiotensin Converting Enzyme Genes on Cardiac Remodeling in Rats with Heart Failure
To investigate the effects of angiotensin converting enzyme 2 and angiotensin converting enzyme genes on the cardiac remodeling process in heart failure rats. 38 rats were randomly divided into sham-operated group (S group), heart failure group (H group) …
Publication
3D-Printed Scaffolds Promote Angiogenesis by Recruiting Antigen-Specific T Cells
The immune response after implantation is a primary determinant of the tissue-repair effects of three- dimensional (3D)-printed scaffolds. Thus, scaffolds that can subtly regulate immune responses may dis- play extraordinary functions. Inspired by the …
Publication
Early Detection and Reversal of Cell Apoptosis Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Opening
Focused ultrasound (FUS) combined with microbubbles (MBs) has recently emerged as a potential approach to open the blood-brain barrier (BBB) for delivering drugs into the brain. However, appropriate approaches are still lacking to monitor the sublethal …
Publication
A neonatal leporine model of age-dependent natural heart regeneration after myocardial infarction
Objectives: Neonatal rodents and piglets naturally regenerate the injured heart after myocardial infarction. We hypothesized that neonatal rabbits also exhibit natural heart regeneration after myocardial infarction. Methods: New Zealand white rabbit kits …